Kalimi M
Mech Ageing Dev. 1984 Feb;24(2):129-38. doi: 10.1016/0047-6374(84)90065-4.
Glucocorticoid responses are known to be altered during development and aging in many tissues. Therefore, in the past several years considerable attention has been given to determining if glucocorticoid receptors are altered with age. In this review, studies concerning glucocorticoid receptor ontogenic and age-dependent changes in number, affinity and physicochemical properties are summarized. In addition, possible mechanisms of age-related changes in the receptor are discussed along with future goals and approaches which may be of great importance in this area of research.
已知在许多组织的发育和衰老过程中，糖皮质激素反应会发生改变。因此，在过去几年中，人们相当关注确定糖皮质激素受体是否会随年龄而改变。在这篇综述中，总结了有关糖皮质激素受体个体发生以及数量、亲和力和物理化学性质的年龄依赖性变化的研究。此外，还讨论了受体中与年龄相关变化的可能机制，以及在该研究领域可能非常重要的未来目标和方法。
