Vaziri N D
West J Med. 1984 Apr;140(4):575-82.
Malignant or accelarated hypertension is a life-threatening medical emergency that is a possible complication of practically any hypertensive disorder. If not promptly treated it can cause severe, rapidly progressive target-organ damage and death. While the histo-pathologic features of malignant hypertension are well recognized, the pathogenesis of the associated vascular lesions and the transition from a benign to a malignant phase are unclear. With adequate control of hypertension, progression to the accelarated or malignant phase can be prevented. Moreover, promptly and effectively reducing the blood pressure during the malignant phase can prevent, minimize or even reverse serious target organ injury. Malignant hypertension, therefore, is both preventable and treatable.
恶性高血压或急进性高血压是一种危及生命的医疗急症，实际上是任何高血压疾病都可能出现的并发症。若不及时治疗，它可导致严重的、迅速进展的靶器官损害甚至死亡。虽然恶性高血压的组织病理学特征已得到充分认识，但相关血管病变的发病机制以及从良性阶段向恶性阶段的转变尚不清楚。通过充分控制高血压，可预防进展至急进性或恶性阶段。此外，在恶性阶段迅速有效地降低血压可预防、减轻甚至逆转严重的靶器官损伤。因此，恶性高血压是可预防且可治疗的。
