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Chloramphenicol acetyltransferase should not provide methanogens with resistance to chloramphenicol.

作者信息

Beckler G S, Hook L A, Reeve J N

出版信息

Appl Environ Microbiol. 1984 Apr;47(4):868-9. doi: 10.1128/aem.47.4.868-869.1984.

DOI:10.1128/aem.47.4.868-869.1984
PMID:6372691
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC239778/
Abstract

Growth of the four methanogens investigated was inhibited by chloramphenicol-3-acetate; therefore, introduction of chloramphenicol acetyltransferase-encoding genes should not confer chloramphenicol resistance on these methanogens. Reduction of the aryl nitro group of chloramphenicol produced a compound which did not inhibit the growth of these methanogens.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef4/239778/a284a2b89acf/aem00161-0281-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef4/239778/a284a2b89acf/aem00161-0281-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ef4/239778/a284a2b89acf/aem00161-0281-a.jpg

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本文引用的文献

1
The decomposition of chloromycetin (chloramphenicol) by microorganisms.
Arch Biochem. 1950 Sep;28(2):232-41.
2
The application of paper-partition chromatography to the analysis of chloramphenicol (chloromycetin) and decomposition products.
Arch Biochem. 1950 Aug;28(1):1-9.
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Beginning genetics with methanogens.从产甲烷菌开始研究遗传学。
Basic Life Sci. 1982;19:233-44. doi: 10.1007/978-1-4684-4142-0_19.
4
Generation of dominant selectable markers for resistance to pseudomonic acid by cloning and mutagenesis of the ileS gene from the archaeon Methanosarcina barkeri fusaro.
通过克隆和诱变古菌巴氏甲烷八叠球菌富萨罗菌株的ileS基因,生成对假单胞菌酸具有抗性的显性选择标记。
J Bacteriol. 2000 May;182(9):2611-8. doi: 10.1128/JB.182.9.2611-2618.2000.
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Neomycin resistance as a selectable marker in Methanococcus maripaludis.新霉素抗性作为沼泽甲烷球菌中的一个选择标记。
Appl Environ Microbiol. 1996 Nov;62(11):4233-7. doi: 10.1128/aem.62.11.4233-4237.1996.
5
Methanosarcina mutant unable to produce methane or assimilate carbon from acetate.无法产生甲烷或从乙酸盐中同化碳的甲烷八叠球菌突变体。
J Bacteriol. 1985 Nov;164(2):618-25. doi: 10.1128/jb.164.2.618-625.1985.
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Analysis of drug resistance in the archaebacterium Methanococcus voltae with respect to potential use in genetic engineering.关于在基因工程中的潜在用途对沃氏甲烷球菌古细菌耐药性的分析。
Appl Environ Microbiol. 1988 Mar;54(3):734-40. doi: 10.1128/aem.54.3.734-740.1988.
The Ferredoxin-dependent reduction of chloramphenicol by clostridium acetobutylicum.
丙酮丁醇梭菌对氯霉素的铁氧化还原蛋白依赖性还原作用。
J Gen Microbiol. 1971 Aug;67(3):265-71. doi: 10.1099/00221287-67-3-265.
5
Solubilization and properties of a particulate hydrogenase from Methanobacterium strain G2R.来自甲烷杆菌菌株G2R的颗粒状氢化酶的增溶作用及性质
J Bacteriol. 1979 Jul;139(1):231-8. doi: 10.1128/jb.139.1.231-238.1979.