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使用抗体包被的聚丙烯酰胺微珠检测慢性免疫性血小板减少性紫癜中的血小板相关IgG

Detection of platelet-associated IgG in chronic immune thrombocytopenic purpura using antibody-coated polyacrylamide beads.

作者信息

Pecze K, Pfliegler G, Dalmi L, Kiss A, Rak K

出版信息

Blut. 1984 May;48(5):291-5. doi: 10.1007/BF00320400.

DOI:10.1007/BF00320400
PMID:6372902
Abstract

Platelet-associated IgG (PAIgG) was detected by means of anti-human IgG coated polyacrylamide beads ("Immunobeads") technique in 32 patients with chronic ITP. Both a direct test (with in vivo sensitized platelets) and an indirect test (with in vitro loaded platelets) were carried out. The percent of rosette forming beads was both in the direct test (41.2%) and in the indirect test (32.6%) significantly higher in the cases of chronic ITP patients than in the controls (2.5% and 3.2%, respectively). These results confirm the diagnostic value of this new, relatively simple and rapid method in routine clinical practice.

摘要

采用抗人IgG包被的聚丙烯酰胺微珠(“免疫微珠”)技术,对32例慢性特发性血小板减少性紫癜(ITP)患者检测血小板相关IgG(PAIgG)。同时进行了直接试验(体内致敏血小板)和间接试验(体外加载血小板)。慢性ITP患者直接试验(41.2%)和间接试验(32.6%)中形成玫瑰花结的微珠百分比均显著高于对照组(分别为2.5%和3.2%)。这些结果证实了这种新的、相对简单快速的方法在常规临床实践中的诊断价值。

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Detection of platelet-associated IgG in chronic immune thrombocytopenic purpura using antibody-coated polyacrylamide beads.使用抗体包被的聚丙烯酰胺微珠检测慢性免疫性血小板减少性紫癜中的血小板相关IgG
Blut. 1984 May;48(5):291-5. doi: 10.1007/BF00320400.
2
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引用本文的文献

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本文引用的文献

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Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura.血小板减少性紫癜患者血液中血小板减少因子的证明。
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Platelet-associated IgG in acute and chronic hepatic diseases.急慢性肝病中的血小板相关免疫球蛋白
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The clinical significance of platelet-associated IgG: a study on 298 patients with various disorders.血小板相关IgG的临床意义:对298例患有各种疾病患者的研究。
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Detection of platelet antibody using rosette technique with anti-IgG antibody-coated polyacrylamide gel: a preliminary report.使用抗IgG抗体包被的聚丙烯酰胺凝胶玫瑰花结技术检测血小板抗体:初步报告。
Vox Sang. 1980 Nov;39(5):264-70. doi: 10.1111/j.1423-0410.1980.tb01869.x.
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Chronic idiopathic thrombocytopenic purpura.慢性特发性血小板减少性紫癜
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Comparison of two direct assays for platelet-associated IgG (PAIgG) in assessement of immune and nonimmune thrombocytopenia.两种直接检测血小板相关IgG(PAIgG)的方法在评估免疫性和非免疫性血小板减少症中的比较。
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Platelet antibody levels do not correlate with response to therapy in idiopathic thrombocytopenic purpura.血小板抗体水平与特发性血小板减少性紫癜的治疗反应无关。
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Lymphocytes bearing both T and B markers in lymphoproliferative disorders.淋巴细胞增生性疾病中同时带有T和B标记的淋巴细胞。
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Autoimmune platelet destruction: idiopathic thrombocytopenic purpura.自身免疫性血小板破坏:特发性血小板减少性紫癜。
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Autoimmune thrombocytopenic purpura.自身免疫性血小板减少性紫癜
Blood. 1980 Sep;56(3):329-43.