全身淋巴照射可预防Bio-Breeding/Worcester（BB/W）大鼠患糖尿病。

Total lymphoid irradiation prevents diabetes mellitus in the Bio-Breeding/Worcester (BB/W) rat.

作者信息

Rossini A A, Slavin S, Woda B A, Geisberg M, Like A A, Mordes J P

出版信息

Diabetes. 1984 Jun;33(6):543-7. doi: 10.2337/diab.33.6.543.

DOI:10.2337/diab.33.6.543

Abstract

Total lymphoid irradiation (TLI) at doses of 2200 rads or greater prevented diabetes in susceptible BB/W rats. Two of 29 (7%) treated rats became diabetic compared with 23 of 39 (59%) controls (P less than 0.001). TLI did not, however, prevent insulitis or thyroiditis in nondiabetic rats, nor did it restore the depressed concanavalin-A responsiveness of BB rat lymphocytes. T-lymphocyte subset proportions were the same in both groups. TLI was associated with significant radiation-related mortality, and nondiabetic TLI-treated rats weighed significantly less than controls. We conclude that TLI is effective in the prevention of BB rat diabetes. However, TLI fails to correct the subclinical immunologic abnormalities of the model and is associated with significant morbidity.

摘要

对易感的BB/W大鼠给予2200拉德或更高剂量的全身淋巴照射（TLI）可预防糖尿病。29只接受治疗的大鼠中有2只（7%）患糖尿病，而39只对照大鼠中有23只（59%）患糖尿病（P<0.001）。然而，TLI并不能预防非糖尿病大鼠的胰岛炎或甲状腺炎，也不能恢复BB大鼠淋巴细胞对刀豆球蛋白A反应性的降低。两组的T淋巴细胞亚群比例相同。TLI与显著的辐射相关死亡率有关，接受TLI治疗的非糖尿病大鼠体重明显低于对照组。我们得出结论，TLI在预防BB大鼠糖尿病方面是有效的。然而，TLI未能纠正该模型的亚临床免疫异常，且与显著的发病率相关。