Handler E S, Mordes J P, Seals J, Koevary S, Like A A, Nakano K, Rossini A A
J Clin Invest. 1985 Oct;76(4):1692-4. doi: 10.1172/JCI112156.
Injections of media conditioned by concanavalin A-activated spleen cells from acutely diabetic rats accelerated the appearance of diabetes in young Bio-Breeding/Worcester (BB/W) rats. Activity was also found in media conditioned by spleen cells from nondiabetic, W-line Wistar Furth and Buffalo rats. Unconditioned media containing mitogen had no activity. Conditioned media also induced diabetes in resistant W-line BB/W rats but not in Wistar Furth rats. A soluble factor may activate a BB lymphocyte population that promotes diabetes.
用急性糖尿病大鼠经伴刀豆球蛋白A激活的脾细胞处理过的培养基进行注射,加速了年轻的Bio-Breeding/Worcester(BB/W)大鼠糖尿病的出现。在非糖尿病的W系Wistar Furth大鼠和布法罗大鼠的脾细胞处理过的培养基中也发现了活性。含有丝裂原的未处理培养基没有活性。处理过的培养基也能诱导抗性W系BB/W大鼠患糖尿病,但不能诱导Wistar Furth大鼠患糖尿病。一种可溶性因子可能激活促进糖尿病的BB淋巴细胞群体。