• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Diabetes in the Bio-Breeding/Worcester rat. Induction and acceleration by spleen cell-conditioned media.生物繁殖/伍斯特大鼠中的糖尿病。脾细胞条件培养基的诱导和加速作用。
J Clin Invest. 1985 Oct;76(4):1692-4. doi: 10.1172/JCI112156.
2
Passive transfer of diabetes from BB/W to Wistar-Furth rats.糖尿病从BB/W大鼠到Wistar-Furth大鼠的被动转移。
J Clin Invest. 1985 Jun;75(6):1904-7. doi: 10.1172/JCI111904.
3
Spleen cell transfusion in the Bio-Breeding/Worcester rat. Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells.生物繁殖/伍斯特大鼠中的脾细胞输血。糖尿病的预防、主要组织相容性复合体限制以及输血细胞的长期存活。
J Clin Invest. 1986 Apr;77(4):1399-401. doi: 10.1172/JCI112448.
4
Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat.淋巴细胞输注可预防生物繁殖/伍斯特大鼠患糖尿病。
J Clin Invest. 1984 Jul;74(1):39-46. doi: 10.1172/JCI111416.
5
Adoptive transfer of autoimmune diabetes mellitus in biobreeding/Worcester (BB/W) inbred and hybrid rats.生物繁殖型/伍斯特（BB/W）近交系和杂交大鼠自身免疫性糖尿病的过继转移
J Immunol. 1985 Mar;134(3):1583-7.
6
Prevention of diabetes in BB/Wor rat by single transfusion of spleen cells. Parameters that affect degree of protection.通过单次输注脾细胞预防BB/Wor大鼠糖尿病。影响保护程度的参数。
Diabetes. 1989 Jan;38(1):24-30. doi: 10.2337/diab.38.1.24.
7
Irradiated lymphocytes do not adoptively transfer diabetes or prevent spontaneous disease in the BB/W rat.经照射的淋巴细胞不能通过过继转移使BB/W大鼠患糖尿病，也不能预防其自发性疾病。
Metabolism. 1986 Jun;35(6):552-4. doi: 10.1016/0026-0495(86)90014-4.
8
Spontaneous diabetes mellitus in the Bio-Breeding/Worcester rat. Evidence in vitro for natural killer cell lysis of islet cells.Bio-Breeding/Worcester大鼠的自发性糖尿病。胰岛细胞自然杀伤细胞裂解的体外证据。
J Clin Invest. 1986 Mar;77(3):916-24. doi: 10.1172/JCI112390.
9
[An experimental study of spontaneously diabetic Bio Breeding/Worcester (BB/W) rats--with special references to the rat MHC (RT1) in the development of the disease].自发性糖尿病Bio Breeding/Worcester（BB/W）大鼠的实验研究——特别提及大鼠主要组织相容性复合体（RT1）在该疾病发展中的作用
Hokkaido Igaku Zasshi. 1989 May;64(3):349-62.
10
Quantitative analyses comparing all major spleen cell phenotypes in BB and normal rats: autoimmune imbalance and double negative T cells associated with resistant, prone and diabetic animals.比较BB大鼠和正常大鼠所有主要脾细胞表型的定量分析：与抗性、易感性和糖尿病动物相关的自身免疫失衡和双阴性T细胞。
J Autoimmun. 1992 Jun;5(3):305-18. doi: 10.1016/0896-8411(92)90145-g.

引用本文的文献

1
Major histocompatibility complex gene product expression on pancreatic beta cells in acutely diabetic BB rats.急性糖尿病BB大鼠胰腺β细胞上主要组织相容性复合体基因产物的表达
Am J Pathol. 1988 Jan;130(1):156-62.

本文引用的文献

1
T lymphocytes of young and aged rats. I. Distribution, density, and capping of T antigens.年轻和老年大鼠的T淋巴细胞。I. T抗原的分布、密度和帽化
J Immunol. 1981 Jul;127(1):149-53.
2
Passive transfer of diabetes in the BB/W rat.BB/W大鼠糖尿病的被动转移
Science. 1983 May 13;220(4598):727-8. doi: 10.1126/science.6836309.
3
Spontaneous autoimmune diabetes mellitus in the BB rat.BB大鼠自发性自身免疫性糖尿病
Diabetes. 1982;31(Suppl 1 Pt 2):7-13. doi: 10.2337/diab.31.1.s7.
4
Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat.淋巴细胞输注可预防生物繁殖/伍斯特大鼠患糖尿病。
J Clin Invest. 1984 Jul;74(1):39-46. doi: 10.1172/JCI111416.
5
Spontaneous autoimmune diabetes mellitus in the BioBreeding/Worcester rat.BioBreeding/Worcester大鼠中的自发性自身免疫性糖尿病
Surv Synth Pathol Res. 1984;3(2):131-8. doi: 10.1159/000156921.
6
Altered immunity and diabetes in the BB rat.BB大鼠的免疫改变与糖尿病
Clin Exp Immunol. 1984 Jul;57(1):1-11.
7
Total lymphoid irradiation prevents diabetes mellitus in the Bio-Breeding/Worcester (BB/W) rat.全身淋巴照射可预防Bio-Breeding/Worcester（BB/W）大鼠患糖尿病。
Diabetes. 1984 Jun;33(6):543-7. doi: 10.2337/diab.33.6.543.
8
Two genes required for diabetes in BB rats. Evidence from cyclical intercrosses and backcrosses.BB大鼠患糖尿病所需的两个基因。来自周期性互交和回交的证据。
J Exp Med. 1984 Jun 1;159(6):1629-36. doi: 10.1084/jem.159.6.1629.
9
Adoptive transfer of autoimmune diabetes mellitus in biobreeding/Worcester (BB/W) inbred and hybrid rats.生物繁殖型/伍斯特（BB/W）近交系和杂交大鼠自身免疫性糖尿病的过继转移
J Immunol. 1985 Mar;134(3):1583-7.

生物繁殖/伍斯特大鼠中的糖尿病。脾细胞条件培养基的诱导和加速作用。

Diabetes in the Bio-Breeding/Worcester rat. Induction and acceleration by spleen cell-conditioned media.

作者信息

Handler E S, Mordes J P, Seals J, Koevary S, Like A A, Nakano K, Rossini A A

出版信息

J Clin Invest. 1985 Oct;76(4):1692-4. doi: 10.1172/JCI112156.

DOI:10.1172/JCI112156
PMID:4056046
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC424167/
Abstract

Injections of media conditioned by concanavalin A-activated spleen cells from acutely diabetic rats accelerated the appearance of diabetes in young Bio-Breeding/Worcester (BB/W) rats. Activity was also found in media conditioned by spleen cells from nondiabetic, W-line Wistar Furth and Buffalo rats. Unconditioned media containing mitogen had no activity. Conditioned media also induced diabetes in resistant W-line BB/W rats but not in Wistar Furth rats. A soluble factor may activate a BB lymphocyte population that promotes diabetes.

摘要

用急性糖尿病大鼠经伴刀豆球蛋白A激活的脾细胞处理过的培养基进行注射，加速了年轻的Bio-Breeding/Worcester（BB/W）大鼠糖尿病的出现。在非糖尿病的W系Wistar Furth大鼠和布法罗大鼠的脾细胞处理过的培养基中也发现了活性。含有丝裂原的未处理培养基没有活性。处理过的培养基也能诱导抗性W系BB/W大鼠患糖尿病，但不能诱导Wistar Furth大鼠患糖尿病。一种可溶性因子可能激活促进糖尿病的BB淋巴细胞群体。