生物繁殖/伍斯特大鼠中的糖尿病。脾细胞条件培养基的诱导和加速作用。

Diabetes in the Bio-Breeding/Worcester rat. Induction and acceleration by spleen cell-conditioned media.

作者信息

Handler E S, Mordes J P, Seals J, Koevary S, Like A A, Nakano K, Rossini A A

出版信息

J Clin Invest. 1985 Oct;76(4):1692-4. doi: 10.1172/JCI112156.

DOI:10.1172/JCI112156

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC424167/

Abstract

Injections of media conditioned by concanavalin A-activated spleen cells from acutely diabetic rats accelerated the appearance of diabetes in young Bio-Breeding/Worcester (BB/W) rats. Activity was also found in media conditioned by spleen cells from nondiabetic, W-line Wistar Furth and Buffalo rats. Unconditioned media containing mitogen had no activity. Conditioned media also induced diabetes in resistant W-line BB/W rats but not in Wistar Furth rats. A soluble factor may activate a BB lymphocyte population that promotes diabetes.

摘要

用急性糖尿病大鼠经伴刀豆球蛋白A激活的脾细胞处理过的培养基进行注射，加速了年轻的Bio-Breeding/Worcester（BB/W）大鼠糖尿病的出现。在非糖尿病的W系Wistar Furth大鼠和布法罗大鼠的脾细胞处理过的培养基中也发现了活性。含有丝裂原的未处理培养基没有活性。处理过的培养基也能诱导抗性W系BB/W大鼠患糖尿病，但不能诱导Wistar Furth大鼠患糖尿病。一种可溶性因子可能激活促进糖尿病的BB淋巴细胞群体。

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引用本文的文献

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Major histocompatibility complex gene product expression on pancreatic beta cells in acutely diabetic BB rats.急性糖尿病BB大鼠胰腺β细胞上主要组织相容性复合体基因产物的表达

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本文引用的文献

1

T lymphocytes of young and aged rats. I. Distribution, density, and capping of T antigens.年轻和老年大鼠的T淋巴细胞。I. T抗原的分布、密度和帽化

J Immunol. 1981 Jul;127(1):149-53.

2

Passive transfer of diabetes in the BB/W rat.BB/W大鼠糖尿病的被动转移

Science. 1983 May 13;220(4598):727-8. doi: 10.1126/science.6836309.

3

Spontaneous autoimmune diabetes mellitus in the BB rat.BB大鼠自发性自身免疫性糖尿病

Diabetes. 1982;31(Suppl 1 Pt 2):7-13. doi: 10.2337/diab.31.1.s7.

4

Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat.淋巴细胞输注可预防生物繁殖/伍斯特大鼠患糖尿病。

J Clin Invest. 1984 Jul;74(1):39-46. doi: 10.1172/JCI111416.

5

Spontaneous autoimmune diabetes mellitus in the BioBreeding/Worcester rat.BioBreeding/Worcester大鼠中的自发性自身免疫性糖尿病

Surv Synth Pathol Res. 1984;3(2):131-8. doi: 10.1159/000156921.

6

Altered immunity and diabetes in the BB rat.BB大鼠的免疫改变与糖尿病

Clin Exp Immunol. 1984 Jul;57(1):1-11.

7

Total lymphoid irradiation prevents diabetes mellitus in the Bio-Breeding/Worcester (BB/W) rat.全身淋巴照射可预防Bio-Breeding/Worcester（BB/W）大鼠患糖尿病。

Diabetes. 1984 Jun;33(6):543-7. doi: 10.2337/diab.33.6.543.

8

Two genes required for diabetes in BB rats. Evidence from cyclical intercrosses and backcrosses.BB大鼠患糖尿病所需的两个基因。来自周期性互交和回交的证据。

J Exp Med. 1984 Jun 1;159(6):1629-36. doi: 10.1084/jem.159.6.1629.

9

Adoptive transfer of autoimmune diabetes mellitus in biobreeding/Worcester (BB/W) inbred and hybrid rats.生物繁殖型/伍斯特（BB/W）近交系和杂交大鼠自身免疫性糖尿病的过继转移

J Immunol. 1985 Mar;134(3):1583-7.

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