肿瘤启动子导致小鼠成纤维细胞微丝紊乱。
Disorganization of microfilaments caused by tumor promoters in mouse fibroblasts.
作者信息
Sakiyama S, Hiwasa T
出版信息
Gan. 1984 Jan;75(1):4-7.
PMID:6373471
Abstract
The effect of tumor promoters on the organization of BALB/c 3T3 fibroblasts was examined by indirect immunofluorescence microscopy using anti-actin antibodies. Potent tumor promoters such as 12-O-tetradecanoylphorbol-13-acetate, teleocidin, dihydroteleocidin B and debromoaplysiatoxin , in spite of their different chemical structures, all induced disruption of microfilaments. This change was still observed in the presence of actinomycin D.
摘要
利用抗肌动蛋白抗体，通过间接免疫荧光显微镜检查了肿瘤启动子对BALB/c 3T3成纤维细胞组织的影响。尽管其化学结构不同，但强效肿瘤启动子如12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯、杀鱼菌素、二氢杀鱼菌素B和脱溴海兔毒素，均能诱导微丝的破坏。在放线菌素D存在的情况下，仍可观察到这种变化。
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