人血清中胸腺组织抗体的检测。
Detection of antibodies to thymic tissue in human serum.
作者信息
Singh V K, Hoffman M A
出版信息
Immunol Lett. 1984;7(5):249-52. doi: 10.1016/0165-2478(84)90030-0.
PMID:6373578
Abstract
Antibodies specific to thymic tissue were detected in normal human serum by means of an indirect immunofluorescent technique. Approximately 50-88% of the total sera (33) showed positive staining, which was confined to the medullary zone primarily associated with the surface membranes of epithelial cells including Hassall's corpuscles. These observations point to the recognition by the immune-self of antigen(s) of the thymic epithelium in health, and presumably in disease.
摘要
采用间接免疫荧光技术在正常人血清中检测到了针对胸腺组织的抗体。在总共33份血清样本中，约50%-88%呈现阳性染色，染色主要局限于髓质区，主要与包括哈氏小体在内的上皮细胞表面膜相关。这些观察结果表明，在健康状态下，或许在疾病状态下，免疫自身可识别胸腺上皮的抗原。
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