Beletskaya L V, Gnesditskaya E V
Scand J Immunol. 1980;12(2):93-8. doi: 10.1111/j.1365-3083.1980.tb00045.x.
Using pemphigus sera containing high titres (1:1000) of non-species-specific antibodies to tissue-specific intercellular substance (ICS) antigen(s) of cover stratified epithelia (skin, oesophagus, vagina and so forth), we detected analogous antigen(s) by immunofluorescence in the ICS of the epithelium of Hassall's corpuscles of human and animal thymus. The results obtained, together with well-known data from histological and embryological studies, confirm the histogenetic relationship of the epithelium of thymus corpuscles and cover epithelia of ectodermal origin. ICS antigen(s) is related to the series of hetero-organic antigens, which probably take part in the natural immunological tolerance formation to the antigens of the organism's own tissues.
利用含有高滴度（1:1000）针对覆盖分层上皮（皮肤、食道、阴道等）组织特异性细胞间物质（ICS）抗原的非物种特异性抗体的天疱疮血清，我们通过免疫荧光在人和动物胸腺哈氏小体上皮的ICS中检测到类似抗原。所获得的结果，连同组织学和胚胎学研究的已知数据，证实了胸腺小体上皮与外胚层来源的覆盖上皮之间的组织发生关系。ICS抗原与一系列异源有机抗原相关，这些抗原可能参与了对机体自身组织抗原的天然免疫耐受形成。
