Popovich R P, Moncrief J W, Nolph K D, Ghods A J, Twardowski Z J, Pyle W K
Ann Intern Med. 1978 Apr;88(4):449-56. doi: 10.7326/0003-4819-88-4-449.
The technique of continuous ambulatory peritoneal dialysis was evaluated in nine patients during 136 patient weeks. The major objectives were to see if continuous ambulatory peritoneal dialysis would provide [1] acceptable control of serum chemistries by usual criteria, [2] adequate removal of sodium and water, [3] tolerable protein losses, and [4] a low prevalence of peritonitis with episodes responsive to therapy with continuing continuous ambulatory peritoneal dialysis. Preliminary findings suggest continuous ambulatory peritoneal dialysis represents an effective ambulatory, portable, internal dialysis technique. Larger-solute clearances per week may approach values six times greater than with most hemodialysis techniques. Small-solute clearances approach dialysate flow rate (8.3 ml/min) and are comparable to other dialysis techniques on a weekly basis. Edema is readily controlled and protein losses should be tolerable with adequate protein intake. Peritonitus occurs on the average every 10 weeks but responds to therapy promptly with continuing continuous ambulatory peritoneal dialysis. If the prevalence of peritonitis can be reduced, continuous ambulatory peritoneal dialysis appears to represent a very attractive dialysis technique.
在136个患者周期间，对9名患者评估了持续非卧床腹膜透析技术。主要目的是观察持续非卧床腹膜透析是否能[1]按照通常标准对血清化学指标进行可接受的控制，[2]充分清除钠和水，[3]使蛋白质丢失量可耐受，以及[4]腹膜炎的发生率低且发作时对持续非卧床腹膜透析治疗有反应。初步研究结果表明，持续非卧床腹膜透析是一种有效的非卧床、便携式体内透析技术。每周较大溶质清除率可能比大多数血液透析技术高六倍。小溶质清除率接近透析液流速（8.3毫升/分钟），且按每周计算与其他透析技术相当。水肿易于控制，蛋白质摄入充足时蛋白质丢失应可耐受。腹膜炎平均每10周发生一次，但持续进行持续非卧床腹膜透析时对治疗反应迅速。如果腹膜炎的发生率能够降低，持续非卧床腹膜透析似乎是一种非常有吸引力的透析技术。
