Wick M R, Moore S B
Mayo Clin Proc. 1984 Jun;59(6):423-8. doi: 10.1016/s0025-6196(12)61467-0.
The recent literature on the technologic and clinical progress being made in renal transplantation has not emphasized applicable advances in blood group serology. Accumulated data on the Lewis blood group system, however, seem to implicate Lewis incompatibilities between kidney donors and recipients as contributing factors in allograft rejection. Lewis antigens may be capable of inciting both cell-mediated and humoral immune responses of a cytotoxic nature, and such antigens are expressed on cell surfaces of the renal parenchyma in Lewis-positive persons. Hence, this serologically defined system could be the source of diminished allograft survival in recipients who are mismatched with their organ donors for Lewis antigens, despite compatibility within other histocompatibility antigen systems. This premise is still open to question, and future, controlled, clinical studies will be necessary to establish a definite role for the Lewis antigen system in renal transplant rejection.
近期有关肾移植技术和临床进展的文献并未强调血型血清学方面的适用进展。然而，关于刘易斯血型系统的累积数据似乎表明，肾供体和受体之间的刘易斯血型不相容是同种异体移植排斥反应的促成因素。刘易斯抗原可能能够引发细胞介导的和具有细胞毒性的体液免疫反应，并且在刘易斯阳性个体的肾实质细胞表面表达此类抗原。因此，尽管在其他组织相容性抗原系统中相匹配，但对于那些与器官供体在刘易斯抗原方面不匹配的受体而言，这个血清学定义的系统可能是同种异体移植物存活期缩短的根源。这一前提仍有待质疑，未来需要进行对照临床研究，以确定刘易斯抗原系统在肾移植排斥反应中的明确作用。
