Oriol R, Opelz G, Chun C, Terasaki P I
Transplantation. 1980 May;29(5):397-400. doi: 10.1097/00007890-198005000-00010.
A significant effect of Lewis antigens on cadaver kidney graft survival was found in 1,300 North American transplants. Lewis-negative recipients had a graft survival rate that was 8% lower than that of Lewis-positive recipients (P = 0.05). This effect of Lewis antigens was enhanced in patients at a high failure risk as determined by age, race, or transplant center. In patients older than 30 years, the effect of Lewis was 14% (P = 0.07), in non-Caucasians 12% (P = 0.07), in all grafts performed at centers with less than 50% overall 1-year graft survival 12% (P = 0.03), and in non-Caucasians that received transplants in centers with less than 50% overall graft survival it was 18% (p = 0.01). These data confirm previous results on the role of Lewis as a histocompatibility system in renal transplantation; furthermore, they demonstrate that the influence of Lewis is larger in patients at high risk.
在1300例北美肾移植手术中，发现Lewis抗原对尸体肾移植存活有显著影响。Lewis阴性受者的移植物存活率比Lewis阳性受者低8%（P = 0.05）。根据年龄、种族或移植中心确定为高失败风险的患者中，Lewis抗原的这种影响更为明显。在30岁以上的患者中，Lewis抗原的影响为14%（P = 0.07），在非白种人中为12%（P = 0.07），在总体1年移植物存活率低于50%的中心进行的所有移植手术中为12%（P = 0.03），在总体移植物存活率低于50%的中心接受移植的非白种人中为18%（P = 0.01）。这些数据证实了之前关于Lewis作为肾移植组织相容性系统作用的研究结果；此外，它们还表明Lewis抗原对高风险患者的影响更大。
