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猫和大鼠基底前脑神经元中胆碱乙酰转移酶样免疫反应性与新皮层注射标记物逆行运输的同步可视化。

Concurrent visualization of choline acetyltransferase-like immunoreactivity and retrograde transport of neocortically injected markers in basal forebrain neurons of cat and rat.

作者信息

Wahle P, Sanides-Buchholtz C, Eckenstein F, Albus K

出版信息

Neurosci Lett. 1984 Feb 24;44(3):223-8. doi: 10.1016/0304-3940(84)90026-0.

DOI:10.1016/0304-3940(84)90026-0
PMID:6374512
Abstract

Magnocellular neurons in the basal forebrain of rats and cats were retrogradely labeled with Fast Blue or horseradish peroxidase injected into the neocortex. Using antisera against choline acetyltransferase (ChAT) a direct double-labeling technique was carried out and it was demonstrated that retrogradely transported markers and ChAT-like immunoreactivity occur within the same neurons. These findings strongly support the cholinergic nature of basal forebrain projection to the neocortex.

摘要

将Fast Blue或辣根过氧化物酶注射到大鼠和猫的新皮质中，对其基底前脑的大细胞神经元进行逆行标记。使用抗胆碱乙酰转移酶（ChAT）抗血清进行直接双重标记技术，结果表明逆行运输标记物和ChAT样免疫反应出现在同一神经元内。这些发现有力地支持了基底前脑向新皮质投射的胆碱能性质。

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Concurrent visualization of choline acetyltransferase-like immunoreactivity and retrograde transport of neocortically injected markers in basal forebrain neurons of cat and rat.猫和大鼠基底前脑神经元中胆碱乙酰转移酶样免疫反应性与新皮层注射标记物逆行运输的同步可视化。
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