Greenan J
Acta Anaesthesiol Scand. 1984 Apr;28(2):182-4. doi: 10.1111/j.1399-6576.1984.tb02037.x.
Glycopyrrolate, 0.2 mg, or atropine, 0.6 mg, was administered intravenously together with methohexitone for the induction of anaesthesia in unpremedicated patients. The use of atropine, compared with glycopyrrolate, was associated with a greater rise in heart rate, a greater number of patients whose heart rates doubled, and a higher incidence of dysrhythmias. Glycopyrrolate is recommended for use as an intravenous anticholinergic agent, particularly in patients with cardiovascular impairment.
对于未使用术前药的患者，在静脉注射美索比妥诱导麻醉时，静脉注射0.2毫克格隆溴铵或0.6毫克阿托品。与格隆溴铵相比，使用阿托品会导致心率升高幅度更大、心率加倍的患者数量更多以及心律失常发生率更高。推荐使用格隆溴铵作为静脉注射抗胆碱能药物，尤其是对于有心血管功能损害的患者。
