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[“巴氏杀菌”剂量的电离辐射对制药化学制造中分离出的微生物耐药性的影响]

[Effect of "pasteurizing" doses of ionizing radiations on the drug resistance of microorganisms isolated in pharmaceutical chemical manufacture].

作者信息

Pavlov E P, Shcheglova S G, Sedov V V

出版信息

Antibiotiki. 1978 Mar;23(3):227-31.

PMID:637529
Abstract

Changes in the antibioticograms after a single irradiation of dry cultures of microorganisms isolated at a pharmaceutical factory were noted in 0.5 per cent of 686 microbial strains tested. Restoration of sensitivity to one or more often several antibiotics was found in the microbes with the changed antibioticograms. After a three-fold irradiation the value increased to 9 per cent. Development of the drug resistance in the microbes neither after the single nor after the three-fold irradiation was observed.

摘要

在一家制药厂分离出的微生物干培养物单次照射后,在所测试的686株微生物菌株中有0.5%的菌株抗菌谱发生了变化。在抗菌谱发生变化的微生物中发现,对一种或多种(通常是几种)抗生素的敏感性得以恢复。经过三次照射后,这一数值增至9%。无论是单次照射还是三次照射后,均未观察到微生物产生耐药性。

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