Detry J M, Block P, De Backer G, Degaute J P
Eur J Clin Pharmacol. 1995;47(6):477-81. doi: 10.1007/BF00193697.
To study patient compliance in hypertensive outpatients amlodipine (5 mg once daily) and slow release nifedipine (20 mg twice daily) were compared in an open, crossover study in general practices. Four methods of assessment for patient compliance (pill count, taking compliance, days with correct dosing, timing compliance) were used in both study arms. For the latter three assessment a special device, the medication event monitoring system, was used to record the time and date of each opening and closure of the container. The compliance of the 320 hypertensive patients with once-daily amlodipine was markedly superior to twice-daily slow release nifedipine. Therapeutic coverage was also significantly better for amlodipine in the hypertensive patients. Amlodipine was better tolerated than nifedipine slow release. Patient compliance and therapeutic coverage with the calcium antagonist amlodipine given once daily was superior to slow release nifedipine b.d. in hypertensive outpatients recruited in general practice.
为研究高血压门诊患者的服药依从性，在一项全科医疗的开放性交叉研究中，对氨氯地平（每日一次，每次5毫克）和缓释硝苯地平（每日两次，每次20毫克）进行了比较。两个研究组均采用了四种评估患者服药依从性的方法（药丸计数、服药依从性、正确服药天数、服药时间依从性）。对于后三种评估，使用了一种特殊装置——药物事件监测系统，来记录容器每次打开和关闭的时间及日期。320例服用每日一次氨氯地平的高血压患者的依从性明显优于服用每日两次缓释硝苯地平的患者。在高血压患者中，氨氯地平的治疗覆盖范围也明显更好。氨氯地平的耐受性优于缓释硝苯地平。在全科医疗招募的高血压门诊患者中，每日一次服用钙拮抗剂氨氯地平的患者依从性和治疗覆盖范围优于每日两次服用缓释硝苯地平的患者。
