Gloor M, Mildenberger K H
Arch Dermatol Res. 1978 Feb 15;261(1):33-8. doi: 10.1007/BF00455373.
A lipid-free preparation containing 0.076% dexamethasone-21-sodium-m-sulfobenzoate (corresponding to 0.05% dexamethasone) has been applied to the right side of the back and the same vehicle without the agent to the left side of the back of 16 male subjects without any skin diseases. The applications were made twice daily over a period of 26 days. Two days after the final application the skin surface lipids were analysed quantitatively by means of the direct extraction method and the paper absorption method. Thin layer chromatograpical analyses were also carried out. The sum of skin surface lipids is not altered by dexamethasone-21-sodium-m-sulfobenzoate. This agent does, however, induce a significant increase in the free fatty acids at the expense of the triglycerides. The importance of this result is discussed with reference to the pathogenesis of steroid acne.
一种不含脂质的制剂，含有0.076%的地塞米松-21-钠间磺基苯甲酸盐（相当于0.05%的地塞米松），已被涂抹于16名无任何皮肤疾病的男性受试者背部右侧，而在其背部左侧涂抹不含该药物的相同赋形剂。每天涂抹两次，持续26天。在最后一次涂抹两天后，通过直接萃取法和纸张吸收法对皮肤表面脂质进行定量分析。还进行了薄层色谱分析。地塞米松-21-钠间磺基苯甲酸盐不会改变皮肤表面脂质的总量。然而，该药物确实会导致游离脂肪酸显著增加，同时甘油三酯减少。结合类固醇性痤疮的发病机制对这一结果的重要性进行了讨论。
