On a possible epigenetic mechanism(s) of tumor cell heterogeneity. The role of DNA methylation.

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作者信息

Frost P, Kerbel R S

出版信息

Cancer Metastasis Rev. 1983;2(4):375-8. doi: 10.1007/BF00048568.

DOI:10.1007/BF00048568

PMID:6375860

Abstract

摘要

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引用本文的文献

The development of a malignant tumor is due to a desperate asexual self-cloning process in which cancer stem cells develop the ability to mimic the genetic program of germline cells.恶性肿瘤的发展是由于一种不顾一切的无性自我克隆过程，在此过程中癌症干细胞获得了模仿生殖系细胞基因程序的能力。

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Tumor progression, oncogenes and the evolution of metastatic phenotypic diversity.肿瘤进展、癌基因与转移表型多样性的演变

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Generation of phenotypic diversity and progression in metastatic tumor cells.转移性肿瘤细胞中表型多样性的产生与进展

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本文引用的文献

Heritable alterations in tumor-cell immunogenicity.肿瘤细胞免疫原性的可遗传改变。

Immunol Today. 1982 Feb;3(2):34-6. doi: 10.1016/0167-5699(82)90057-3.

Methylation of deoxycytidine incorporated by excision-repair synthesis of DNA.通过DNA切除修复合成掺入的脱氧胞苷的甲基化。

Cell. 1982 Sep;30(2):509-16. doi: 10.1016/0092-8674(82)90248-3.

Biological diversity in metastatic neoplasms: origins and implications.转移性肿瘤中的生物多样性：起源与影响

Science. 1982 Sep 10;217(4564):998-1003. doi: 10.1126/science.7112116.

Increasing metastatic potential is associated with increasing genetic instability of clones isolated from murine neoplasms.转移潜能的增加与从小鼠肿瘤中分离出的克隆的遗传不稳定性增加相关。

Proc Natl Acad Sci U S A. 1981 Nov;78(11):6949-52. doi: 10.1073/pnas.78.11.6949.

Experimental systems for analysis of the malignant phenotype.用于分析恶性表型的实验系统。

Cancer Metastasis Rev. 1982;1(2):141-99. doi: 10.1007/BF00048224.

Mutagen treatment as a means for selecting immunogenic variants from otherwise poorly immunogenic malignant murine tumors.诱变剂处理作为一种从原本免疫原性较差的恶性小鼠肿瘤中筛选免疫原性变体的手段。

Cancer Res. 1983 Jan;43(1):125-32.

Antigenic tumor cell variants obtained with mutagens.通过诱变剂获得的抗原性肿瘤细胞变体。

Adv Cancer Res. 1983;39:121-51. doi: 10.1016/s0065-230x(08)61034-9.

Inheritance of DNA methylation in microinjected eggs of Xenopus laevis.非洲爪蟾显微注射卵中DNA甲基化的遗传

Proc Natl Acad Sci U S A. 1982 Apr;79(7):2323-7. doi: 10.1073/pnas.79.7.2323.

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