西咪替丁用于预防应激性溃疡。
Cimetidine for stress-ulcer prophylaxis.
作者信息
Greene W L, Bollinger R R
出版信息
Crit Care Med. 1984 Jul;12(7):571-5. doi: 10.1097/00003246-198407000-00005.
Abstract
Although cimetidine is more effective than a placebo for the prophylaxis of stress-induced ulcers, it has no advantage over titrated antacid dosing. Several comparative studies even suggest that combining cimetidine with antacid is no more effective than use of full-dose antacid. Therefore, we recommend prophylactic use of cimetidine only when very large dosages of antacid are required, in order to minimize acid-base disturbances.
摘要
尽管西咪替丁在预防应激性溃疡方面比安慰剂更有效，但与滴定抗酸剂给药相比并无优势。多项比较研究甚至表明，将西咪替丁与抗酸剂联合使用并不比使用全剂量抗酸剂更有效。因此，我们建议仅在需要非常大剂量抗酸剂时预防性使用西咪替丁，以尽量减少酸碱紊乱。
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