Golin J E, Esposito M S
Genetics. 1984 Jul;107(3):355-65. doi: 10.1093/genetics/107.3.355.
During mitosis, gene conversion events at the TRP5 locus on chromosome VII are coupled with conversion events at LEU1, a locus 18 cM away, 1200 times more frequently than would be expected for two independent acts of recombination. Such coincident conversion events that occur over relatively long distances could be due to several mechanisms. We discuss these possibilities and describe an experiment that indicates that a portion of coincident events is due to extensive heteroduplexes. The phenomenon of coincident gene conversion is discussed in relation to our earlier evidence that spontaneous recombination between homologues occurs prereplicationally in mitosis.
在有丝分裂期间,VII号染色体上TRP5位点的基因转换事件与距离该位点18厘摩的LEU1位点的转换事件相关联,其发生频率比两个独立重组事件预期的频率高1200倍。这种在相对较长距离上发生的同时性转换事件可能由多种机制引起。我们讨论了这些可能性,并描述了一项实验,该实验表明部分同时性事件是由于广泛的异源双链体所致。结合我们之前关于同源染色体之间的自发重组在有丝分裂的复制前发生的证据,对同时性基因转换现象进行了讨论。