重复基因间基因转换的速率和片段长度。

Graduate University for Advanced Studies, Hayama, Kanagawa 240-0193, Japan.

Genes (Basel). 2011 Mar 25;2(2):313-31. doi: 10.3390/genes2020313.

Interlocus gene conversion occurs such that a certain length of DNA fragment is non-reciprocally transferred (copied and pasted) between paralogous regions. To understand the rate and tract length of gene conversion, there are two major approaches. One is based on mutation-accumulation experiments, and the other uses natural DNA sequence variation. In this review, we overview the two major approaches and discuss their advantages and disadvantages. In addition, to demonstrate the importance of statistical analysis of empirical and evolutionary data for estimating tract length, we apply a maximum likelihood method to several data sets.

基因座间基因转换会导致特定长度的 DNA 片段在直系同源区域间发生非交互（复制粘贴）转移。为了了解基因转换的速率和片段长度，有两种主要方法。一种方法基于突变积累实验，另一种则利用自然 DNA 序列变异。在这篇综述中，我们概述了这两种主要方法，并讨论了它们的优缺点。此外，为了证明对经验和进化数据进行统计分析以估计片段长度的重要性，我们应用最大似然法分析了几组数据集。