Coon W W, Penner J, Clagett P, Eos N
Arch Surg. 1978 Apr;113(4):429-31. doi: 10.1001/archsurg.1978.01370160087014.
Eighty-six patients undergoing elective splenectomy have been investigated preoperatively and postoperatively by serial platelet counts and leg scanning using iodine 125-labeled fibrinogen. The presence of deep leg vein thromboses detected by labeled fibrinogen was confirmed by dye phlebography. In only five patients (6%) did deep venous thrombosis develop. In none of these five patients did an elevation in platelet count to 600,000/cu mm develop before or at the time of development of the thrombosis. None of 21 other patients who did have a rise in platelet count greater than 1,000,000/cu mm had evidenced of venous thrombosis. These data do not substantiate the need for routine prophylactic antithrombotic therapy in patients in whom postsplenectomy thrombocytosis develops.
对86例行择期脾切除术的患者在术前和术后进行了连续血小板计数，并使用碘125标记的纤维蛋白原进行腿部扫描。通过标记纤维蛋白原检测到的下肢深静脉血栓形成经静脉造影证实。仅5例患者（6%）发生了深静脉血栓形成。在这5例患者中，无一例在血栓形成之前或形成之时血小板计数升高至600,000/立方毫米。另外21例血小板计数升高超过1,000,000/立方毫米的患者均无静脉血栓形成的证据。这些数据并不支持对发生脾切除术后血小板增多症的患者进行常规预防性抗血栓治疗。
