从宫内硅橡胶装置释放的吲哚美辛对大鼠子宫前列环素基础水平及合成能力的影响。

Influence of indomethacin delivered from an intrauterine silastic device on basal levels and synthesizing capability of rat uterus for prostacyclin.

作者信息

Peplow P V, Hurst P R

出版信息

Prostaglandins Leukot Med. 1984 May;14(2):191-7. doi: 10.1016/0262-1746(84)90202-6.

Abstract

The intrauterine release of indomethacin (approximately 120 micrograms over 23 days) from a unilateral silastic device did not cause any significant reduction in basal levels of PGI2 (determined as 6-keto PGF1 alpha) in the tissue of the IUD horn. However, this tissue was found to have an increased potential for PGI2 synthesis when compared to that of the uterine horn with a plain device. The implications of these findings regarding a possible effect of indomethacin on the myometrium are discussed.

摘要

单侧硅橡胶装置中吲哚美辛在子宫内的释放（23天内约120微克）并未导致宫内节育器（IUD）侧子宫角组织中PGI2（测定为6-酮-PGF1α）的基础水平有任何显著降低。然而，与放置普通装置的子宫角组织相比，发现该组织合成PGI2的潜力增加。讨论了这些发现对于吲哚美辛对子宫肌层可能产生的影响的意义。