吲哚美辛从硅橡胶装置局部释放对子宫前列腺素F2α和E的影响。

Influence of local release of indomethacin from a silastic device on uterine prostaglandins F2 alpha and E.

作者信息

Peplow P V, Hurst P R

出版信息

Prostaglandins Leukot Med. 1982 Oct;9(4):437-44. doi: 10.1016/0262-1746(82)90100-7.

Abstract

Delivery of indomethacin (approximately 120 micrograms over 23 days) from a unilateral silastic intrauterine device in the rat caused a reduction in the wet weight of the IUD-bearing horn when compared to that of animals with a plain silastic device. The exposure of the uterus to the sustained local release of indomethacin also resulted in a lowering of basal levels of prostaglandins PGF2 alpha and PGE in the tissue as determined by radioimmunoassay. For PGF2 alpha, no marked difference was found in the capability of the tissue to produce it when the IUD horns of the two groups of experimental animals were compared.

摘要

与放置普通硅橡胶宫内节育器的大鼠相比，大鼠单侧硅橡胶宫内节育器在23天内释放吲哚美辛（约120微克）导致带宫内节育器侧子宫角湿重减轻。通过放射免疫测定法确定，子宫持续局部释放吲哚美辛也导致组织中前列腺素PGF2α和PGE的基础水平降低。对于PGF2α，比较两组实验动物的宫内节育器子宫角时，未发现组织产生PGF2α的能力有明显差异。