Eb F, Orfila J, Fuentes V, Thomas D, Bissac E
Virologie. 1984 Apr-Jun;35(2):109-17.
The kinetics of antibodies to C. trachomatis and C. psittaci was studied in OF 1 and inbred C 57 Bl mice, inoculated intravenously (IV) or intraperitoneally. Antibodies were detected by a micro-immunofluorescence (MIF) test. Antibody kinetics depends on many factors (genetic particularities of the mice, route of inoculation, chlamydial strain). The response is more specific when mice are inoculated with C. trachomatis than with C. psittaci; heterospecific antibodies appear later in C 57 Bl mice than in OF 1 mice inoculated IV with C. trachomatis. These results are used to explain the serological findings in 6 cases of human chlamydial infections. The type, species and genus specificities of antibody responses to chlamydial infections are discussed.
在OF1和近交C57Bl小鼠中，通过静脉注射（IV）或腹腔注射接种沙眼衣原体和鹦鹉热衣原体后，研究了针对这两种衣原体的抗体动力学。通过微量免疫荧光（MIF）试验检测抗体。抗体动力学取决于许多因素（小鼠的遗传特性、接种途径、衣原体菌株）。当用沙眼衣原体接种小鼠时，反应比用鹦鹉热衣原体接种时更具特异性；在C57Bl小鼠中，异种特异性抗体出现的时间比静脉注射沙眼衣原体的OF1小鼠晚。这些结果用于解释6例人类衣原体感染的血清学发现。讨论了衣原体感染抗体反应的类型、种属特异性。
