Reus W F, Murphy R C, Heggers J P, Robson M C, McCauley R L
Ann Plast Surg. 1984 Jul;13(1):29-33. doi: 10.1097/00000637-198407000-00006.
Previous research has implicated arachidonic acid metabolites in the failure of the distal dying flap. The progressive ischemic necrosis has been postulated to be secondary to excessive thromboxane A2 production, which upsets the normal balance between prostacyclin and thromboxane. We have examined the effect of continuous intraarterial prostacyclin infusion on axial skin flap survival in the pig, in an effort to reestablish homeostasis. We found prostacyclin to have a biphasic effect upon the flap survival. Low-dose locally administered prostacyclin was of benefit in flap salvage; however, the complicated pharmacological effect of the agent is emphasized.
先前的研究表明，花生四烯酸代谢产物与远端坏死皮瓣的坏死有关。渐进性缺血性坏死被认为是由于血栓素A2产生过多所致，这打破了前列环素和血栓素之间的正常平衡。为了重建体内平衡，我们研究了持续动脉内输注前列环素对猪轴型皮瓣存活的影响。我们发现前列环素对皮瓣存活有双相作用。低剂量局部应用前列环素对挽救皮瓣有益；然而，该药物复杂的药理作用也得到了强调。
