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1
The coupling of metabolic to secretory events in pancreatic islets. The cytosolic redox state.胰岛中代谢与分泌事件的偶联。胞质氧化还原状态。
Biochem J. 1984 Jun 1;220(2):433-40. doi: 10.1042/bj2200433.
2
Effects of glucose on the cytosolic ration of reduced/oxidized nicotinamide-adenine dinucleotide phosphate in rat islets of Langerhans.葡萄糖对大鼠胰岛中还原型/氧化型烟酰胺腺嘌呤二核苷酸磷酸细胞溶质比率的影响。
Biochem J. 1979 Dec 15;184(3):697-700. doi: 10.1042/bj1840697.
3
Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion.线粒体丙酮酸-苹果酸穿梭在胰岛中的可行性。胞质烟酰胺腺嘌呤二核苷酸磷酸（NADPH）在胰岛素分泌中的进一步意义。
J Biol Chem. 1995 Aug 25;270(34):20051-8.
4
The coupling of metabolic to secretory events in pancreatic islets: comparison between insulin release and cytosolic redox state.胰岛中代谢与分泌事件的耦合：胰岛素释放与胞质氧化还原状态的比较。
Biochem Int. 1987 May;14(5):897-902.
5
The stimulus-secretion coupling of amino acid-induced insulin release. Secretory and oxidative response of pancreatic islets to L-asparagine.氨基酸诱导的胰岛素释放的刺激-分泌偶联。胰岛对L-天冬酰胺的分泌和氧化反应。
Diabetes. 1984 May;33(5):464-9. doi: 10.2337/diab.33.5.464.
6
Differential sensitivity to beta-cell secretagogues in cultured rat pancreatic islets exposed to human interleukin-1 beta.暴露于人类白细胞介素-1β的培养大鼠胰岛对β细胞促分泌剂的差异敏感性。
Endocrinology. 1989 Aug;125(2):752-9. doi: 10.1210/endo-125-2-752.
7
The stimulus-secretion coupling of amino acid-induced insulin release. Metabolic interaction of L-glutamine and 2-ketoisocaproate in pancreatic islets.氨基酸诱导胰岛素释放的刺激-分泌偶联。胰岛中L-谷氨酰胺与2-酮异己酸的代谢相互作用。
Biochim Biophys Acta. 1981 Sep 18;677(1):39-49. doi: 10.1016/0304-4165(81)90143-4.
8
Enzymes of glucose metabolism in normal mouse pancreatic islets.正常小鼠胰岛中葡萄糖代谢的酶
Biochem J. 1970 Aug;119(1):5-15. doi: 10.1042/bj1190005.
9
Changes in NAD(P)+-dependent malic enzyme and malate dehydrogenase activities during fibroblast proliferation.成纤维细胞增殖过程中NAD(P)+依赖性苹果酸酶和苹果酸脱氢酶活性的变化。
J Cell Physiol. 1982 Feb;110(2):142-8. doi: 10.1002/jcp.1041100206.
10
The role of nicotinamide-adenine dinucleotide phosphate-dependent malate dehydrogenase and isocitrate dehydrogenase in the supply of reduced nicotinamide-adenine dinucleotide phosphate for steroidogenesis in the superovulated rat ovary.烟酰胺腺嘌呤二核苷酸磷酸依赖性苹果酸脱氢酶和异柠檬酸脱氢酶在超排卵大鼠卵巢类固醇生成中提供还原型烟酰胺腺嘌呤二核苷酸磷酸的作用。
Biochem J. 1970 Mar;117(1):73-83. doi: 10.1042/bj1170073.

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1
Kinetic modelling of β-cell metabolism reveals control points in the insulin-regulating pyruvate cycling pathways.β 细胞代谢的动力学建模揭示了胰岛素调节的丙酮酸循环途径中的控制节点。
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Mitochondrial malic enzyme 3 is important for insulin secretion in pancreatic β-cells.线粒体苹果酸酶3对胰腺β细胞中的胰岛素分泌很重要。
Mol Endocrinol. 2015 Mar;29(3):396-410. doi: 10.1210/me.2014-1249. Epub 2015 Jan 16.
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Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line.慢性降低细胞质或线粒体 NAD(P)-苹果酸酶不会影响大鼠胰岛素瘤细胞系的胰岛素分泌。
J Biol Chem. 2009 Dec 18;284(51):35359-67. doi: 10.1074/jbc.M109.040394.
4
Elimination of KATP channels in mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gamma-aminobutyric acid shunt.消除小鼠胰岛中的KATP通道会导致[U-13C]葡萄糖代谢、谷氨酰胺分解和丙酮酸循环增加，但γ-氨基丁酸分流减少。
J Biol Chem. 2008 Jun 20;283(25):17238-49. doi: 10.1074/jbc.M709235200. Epub 2008 Apr 29.
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Fuel-induced amplification of insulin secretion in mouse pancreatic islets exposed to a high sulfonylurea concentration: role of the NADPH/NADP+ ratio.燃料诱导高磺脲浓度下小鼠胰岛胰岛素分泌的放大：NADPH/NADP⁺ 比值的作用
Diabetologia. 2008 Jan;51(1):101-9. doi: 10.1007/s00125-007-0849-z. Epub 2007 Oct 25.
6
Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose.琥珀酸甲酯对胰腺β细胞中Ca2+、NAD(P)H和膜电位的影响：与葡萄糖的比较
Biochem J. 2007 Apr 1;403(1):197-205. doi: 10.1042/BJ20061209.
7
Enzymes in pancreatic islets that use NADP(H) as a cofactor including evidence for a plasma membrane aldehyde reductase.胰岛中以烟酰胺腺嘌呤二核苷酸磷酸（还原型）（NADP(H)）作为辅因子的酶，包括质膜醛还原酶的证据。
Mol Cell Biochem. 2001 Sep;225(1-):151-60. doi: 10.1023/a:1012238709063.
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A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties.在调节胰岛素原生物合成和胰岛素分泌的代谢刺激-反应偶联途径中，存在着一个明显的差异，该差异存在于对脂肪酰基部分的需求层面。
Biochem J. 1998 Apr 15;331 ( Pt 2)(Pt 2):553-61. doi: 10.1042/bj3310553.
9
Subcellular distribution of hexokinase isoenzymes in pancreatic islet cells exposed to digitonin after incubation at a low or high concentration of D-glucose.在低浓度或高浓度D-葡萄糖孵育后，暴露于洋地黄皂苷的胰岛细胞中己糖激酶同工酶的亚细胞分布。
Mol Cell Biochem. 1997 Oct;175(1-2):131-6. doi: 10.1023/a:1006839813344.
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Hexose metabolism in pancreatic islets: effect of D-glucose on the mitochondrial redox state.胰腺胰岛中的己糖代谢：D-葡萄糖对线粒体氧化还原状态的影响。
Mol Cell Biochem. 1995 Jan 12;142(1):43-8. doi: 10.1007/BF00928912.

本文引用的文献

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Convenient rapid determination of picomole amounts of oxaloacetate and aspartate.草酰乙酸和天冬氨酸皮摩尔量的便捷快速测定。
Anal Biochem. 1980 May 15;104(2):296-9. doi: 10.1016/0003-2697(80)90078-0.
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The stimulus-secretion coupling of amino acid-induced insulin release. Metabolic response of pancreatic islets of L-glutamine and L-leucine.氨基酸诱导的胰岛素释放的刺激-分泌偶联。L-谷氨酰胺和L-亮氨酸对胰岛的代谢反应。
J Biol Chem. 1982 Aug 10;257(15):8731-7.
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The stimulus-secretion coupling of glucose-induced insulin release: effect of aminooxyacetate upon nutrient-stimulated insulin secretion.葡萄糖诱导胰岛素释放的刺激-分泌偶联：氨基氧乙酸对营养物质刺激的胰岛素分泌的影响。
Endocrinology. 1982 Aug;111(2):392-7. doi: 10.1210/endo-111-2-392.
4
The stimulus-secretion coupling of glucose-induced insulin release. Environmental influences on L-glutamine oxidation in pancreatic islets.葡萄糖诱导的胰岛素释放的刺激-分泌偶联。环境对胰岛中L-谷氨酰胺氧化的影响。
Biochem J. 1982 Feb 15;202(2):309-16. doi: 10.1042/bj2020309.
5
The stimulus-secretion coupling of glucose-induced insulin release. Thiol: disulfide balance in pancreatic islets.葡萄糖诱导的胰岛素释放的刺激-分泌偶联。胰岛中的硫醇：二硫键平衡。
Biochimie. 1982 Jan;64(1):29-36. doi: 10.1016/s0300-9084(82)80606-8.
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The stimulus-secretion coupling of amino acid-induced insulin release. Metabolic interaction of L-glutamine and 2-ketoisocaproate in pancreatic islets.氨基酸诱导胰岛素释放的刺激-分泌偶联。胰岛中L-谷氨酰胺与2-酮异己酸的代谢相互作用。
Biochim Biophys Acta. 1981 Sep 18;677(1):39-49. doi: 10.1016/0304-4165(81)90143-4.
7
L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase.L-亮氨酸和一种非代谢类似物可激活胰岛谷氨酸脱氢酶。
Nature. 1980 Nov 13;288(5787):187-9. doi: 10.1038/288187a0.
8
The stimulus-secretion coupling of amino acid-induced insulin release. II. Sensitivity to K+, NH4+ and H+ of leucine-stimulated islets.氨基酸诱导的胰岛素释放的刺激-分泌偶联。II. 亮氨酸刺激的胰岛对K⁺、NH₄⁺和H⁺的敏感性
Diabete Metab. 1980 Jun;6(2):97-101.
9
The stimulus-secretion coupling of amino acid-induced insulin release: metabolism and cationic effects of leucine.氨基酸诱导胰岛素释放的刺激-分泌偶联：亮氨酸的代谢及阳离子效应
Diabetes. 1980 Jun;29(6):431-7. doi: 10.2337/diab.29.6.431.
10
The stimulus-secretion coupling of glucose-induced insulin release: fuel metabolism in islets deprived of exogenous nutrient.葡萄糖诱导的胰岛素释放的刺激-分泌偶联：缺乏外源性营养的胰岛中的燃料代谢。
Arch Biochem Biophys. 1983 Jul 1;224(1):102-10. doi: 10.1016/0003-9861(83)90193-5.

胰岛中代谢与分泌事件的偶联。胞质氧化还原状态。

The coupling of metabolic to secretory events in pancreatic islets. The cytosolic redox state.

作者信息

Sener A, Malaisse-Lagae F, Dufrane S P, Malaisse W J

出版信息

Biochem J. 1984 Jun 1;220(2):433-40. doi: 10.1042/bj2200433.

DOI:10.1042/bj2200433
PMID:6378186
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1153644/
Abstract

NADP-linked isocitrate dehydrogenase and malic enzyme [malate dehydrogenase (decarboxylating) (NADP)] activities were characterized in the cytosol of pancreatic islet cells. D-Glucose and L-leucine augmented the cytosolic NADPH/NADP+ ratio, as judged from the isocitrate/2-oxoglutarate and malate/pyruvate islet contents. The flow rate through the malic enzyme was judged from the output of labelled pyruvate by islets exposed to either L-[U-14C]glutamine or L-[U-14C]leucine. The cytosolic generation of NADPH, e.g. at the level of the malic enzyme, may play a role in the coupling of metabolic to secretory events in the process of nutrient-stimulated insulin release.

摘要

在胰岛细胞的胞质溶胶中对烟酰胺腺嘌呤二核苷酸磷酸（NADP）连接的异柠檬酸脱氢酶和苹果酸酶[苹果酸脱氢酶（脱羧）（NADP）]的活性进行了表征。从异柠檬酸/2-氧代戊二酸和苹果酸/丙酮酸的胰岛含量判断，D-葡萄糖和L-亮氨酸可提高胞质溶胶中还原型辅酶II（NADPH）/氧化型辅酶II（NADP⁺）的比率。通过将胰岛暴露于L-[U-¹⁴C]谷氨酰胺或L-[U-¹⁴C]亮氨酸，从标记丙酮酸的输出量来判断通过苹果酸酶的流速。胞质溶胶中NADPH的生成，例如在苹果酸酶水平，可能在营养物质刺激胰岛素释放过程中的代谢与分泌事件偶联中发挥作用。