Longhini C, Musacci G F, Ansani L, Toselli T, Artioli M, Bianco L, Ghirardi P
Eur J Clin Pharmacol. 1983;24(5):585-9. doi: 10.1007/BF00542205.
Peripheral haemodynamics was studied in healthy volunteers by strain gauge plethysmography after administration of ibopamine (IB), diisobutyric ester of N-methyl-dopamine, an orally active dopaminergic agonist. Seven subjects received a single oral dose of ibopamine of 150 mg and 6 received a daily dose of 150 mg (50 mg t.i.d.) for 5 consecutive days. Arterial resting blood flow and venous capacity increased and peripheral resistance decreased significantly. Six further subjects were then studied; 3 h after an oral dose of ibopamine 150 mg, the parenteral administration of Sulpiride 50 mg, a specific vascular dopaminergic antagonist, was found significantly to counteract its peripheral activity. Heart rate and arterial blood pressure were never affected and tolerability was good.
通过应变计体积描记法对健康志愿者服用异波帕明（IB）（N-甲基多巴胺的二异丁酸酯，一种口服活性多巴胺能激动剂）后的外周血流动力学进行了研究。7名受试者单次口服150毫克异波帕明，6名受试者连续5天每日服用150毫克（50毫克，每日三次）。静息动脉血流量和静脉容量增加，外周阻力显著降低。然后对另外6名受试者进行了研究；口服150毫克异波帕明3小时后，发现胃肠外给予50毫克舒必利（一种特异性血管多巴胺能拮抗剂）可显著抵消其外周活性。心率和动脉血压从未受到影响，耐受性良好。
