Girbes A R, van Veldhuisen D J, Smit A J, Drent-Bremer A, Meijer S, Reitsma W D
Department of Internal Medicine, University Hospital Groningen, The Netherlands.
Br J Clin Pharmacol. 1991 Jun;31(6):701-4. doi: 10.1111/j.1365-2125.1991.tb05597.x.
The effects of 100 mg ibopamine, an orally active nonselective dopamine agonist on renal haemodynamics, sodium excretion, blood pressure (BP), heart rate (HR) and neurohumoral parameters were investigated in 10 healthy volunteers, with and without metoclopramide pretreatment. A small and temporary rise of glomerular filtration rate (GFR) was found after ibopamine without but not with metoclopramide pretreatment. No differences in effective renal plasma flow (ERPF) but a small rise in sodium excretion were observed comparing ibopamine with control. Metoclopramide induced a fall in sodium excretion which was not reversed by ibopamine. Ibopamine failed to affect BP and HR and no changes of PRA or plasma aldosterone concentration (PAC) were found. Metoclopramide induced a pronounced increase of PAC which was blunted by ibopamine. Plasma and urinary catecholamines were unchanged for all study days. We conclude that ibopamine induces natriuresis probably not by the observed small and temporary renal haemodynamic effects but by direct stimulation of DA1 dopamine receptors in the proximal tubule.
在10名健康志愿者中，研究了口服活性非选择性多巴胺激动剂100毫克异波帕胺对肾血流动力学、钠排泄、血压（BP）、心率（HR）和神经体液参数的影响，这些志愿者接受或未接受甲氧氯普胺预处理。未接受甲氧氯普胺预处理的志愿者服用异波帕胺后，肾小球滤过率（GFR）出现了小幅度的短暂升高，而接受甲氧氯普胺预处理的志愿者则未出现此现象。与对照组相比，异波帕胺组有效肾血浆流量（ERPF）无差异，但钠排泄略有增加。甲氧氯普胺导致钠排泄减少，异波帕胺未能逆转这一现象。异波帕胺未能影响血压和心率，也未发现肾素活性（PRA）或血浆醛固酮浓度（PAC）有变化。甲氧氯普胺导致PAC显著升高，而异波帕胺可使其减弱。在所有研究日，血浆和尿儿茶酚胺均无变化。我们得出结论，异波帕胺可能不是通过所观察到的微小且短暂的肾血流动力学效应，而是通过直接刺激近端小管中的DA1多巴胺受体来诱导利钠作用。
