DeFries J C, Gervais M C, Thomas E A
Behav Genet. 1978 Jan;8(1):3-13. doi: 10.1007/BF01067700.
High and low lines resulting from 30 generations of bidirectional selection for open-field activity have nonoverlapping distributions and more than a thirtyfold difference in mean activity. Open-field defecation scores of low-active lines are approximately 7 times higher than those of high-active lines, substantiating earlier reports of a large, negative genetic correlation between these characters. Since the selection experiment is replicated, other variables which are found to be reliably different among the high, control, and low lines are likely to be causally related to open-field activity; thus these selected lines of mice may be of use to other investigators.
通过对旷场活动进行30代双向选择所产生的高活动和低活动品系具有不重叠的分布，且平均活动存在三十多倍的差异。低活动品系的旷场排便得分比高活动品系高约7倍，证实了此前关于这些性状之间存在显著负遗传相关性的报道。由于选择实验是重复进行的，在高活动、对照和低活动品系之间发现可靠差异的其他变量可能与旷场活动存在因果关系；因此，这些选择的小鼠品系可能对其他研究人员有用。
