降血糖素对大鼠葡萄糖代谢的影响。一项使用[U-14C,2-3H]葡萄糖的体内动力学研究。
The effects of hypoglycin on glucose metabolism in the rat. A kinetic study in vivo and [U-14C,2-3H]glucose.
作者信息
Osmundsen H, Billington D, Taylor J R, Sherratt H S
出版信息
Biochem J. 1978 Feb 15;170(2):337-42. doi: 10.1042/bj1700337.
Abstract
- The kinetics of glucose metabolism were evaluated in rats deprived of food 15-21 h after the administration of hypoglycaemic doses of hypoglycin (100 mg/kg body wt.) by following changes in the specific radioactivities of 14C and 3H in blood glucose after an intravenous dose of [U-14C,2-3H]glucose [Katz, Rostami & Dunn (1974) Biochem. J. 142, 161-170]. 2. During this time, recycling of glucose through the Cori cycle was virtually abolished, the rate of irreversible disposal of glucose and its total body mass were both decreased by about 70%, whereas there was little effect on the mean transit time for glucose. 3. It was concluded that hypoglycaemia is due to inhibition of gluconeogenesis.
摘要
- 通过静脉注射[U-¹⁴C,2-³H]葡萄糖后，追踪血糖中¹⁴C和³H的比放射性变化，评估了在给予低血糖剂量的次甘氨酸（100mg/kg体重）15 - 21小时后禁食大鼠的葡萄糖代谢动力学[Katz, Rostami & Dunn (1974) Biochem. J. 142, 161 - 170]。2. 在此期间，通过科里循环的葡萄糖再循环几乎被消除，葡萄糖的不可逆处置速率及其总体质量均下降了约70%，而对葡萄糖的平均转运时间影响很小。3. 得出的结论是，低血糖是由于糖异生受到抑制。
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