Brändén C I, Eklund H, Cambillau C, Pryor A J
EMBO J. 1984 Jun;3(6):1307-10. doi: 10.1002/j.1460-2075.1984.tb01967.x.
The intron/exon arrangement in the gene sequence of maize alcohol dehydrogenase has been compared to the three dimensional structure of liver alcohol dehydrogenase. The co-enzyme binding domain is separated from the catalytic domain by introns four and nine. Intron seven separates the co-enzyme binding domain into two structurally similar mononucleotide binding units. The first of these units is divided by introns five and six into three structurally similar alpha beta modules. Implications of these results for protein evolution is discussed. All splice junctions map close to or at the surface of the domains, and several of these cannot be identified by distance maps.
已将玉米醇脱氢酶基因序列中的内含子/外显子排列与肝脏醇脱氢酶的三维结构进行了比较。辅酶结合结构域通过内含子4和9与催化结构域分开。内含子7将辅酶结合结构域分成两个结构相似的单核苷酸结合单元。这些单元中的第一个被内含子5和6分成三个结构相似的αβ模块。讨论了这些结果对蛋白质进化的影响。所有剪接连接都定位在结构域表面附近或表面上，其中几个无法通过距离图识别。
