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一种神经细胞黏附分子的发育生物学

Developmental biology of a neural cell adhesion molecule.

作者信息

Rutishauser U

出版信息

Nature. 1984;310(5978):549-54. doi: 10.1038/310549a0.

DOI:10.1038/310549a0
PMID:6379469
Abstract

A membrane glycoprotein isolated from embryonic brain has been shown to be a ligand in the formation of cell-cell bonds. The molecule, called neural cell adhesion molecule (N-CAM), participates in several aspects of neural development, including the formation of plexiform layers, neurite fasciculation and nerve-muscle interactions. Experiments in vivo indicate that N-CAM-mediated adhesion is essential to the orderly assembly of the visual system.

摘要

从胚胎大脑中分离出的一种膜糖蛋白已被证明是细胞间连接形成过程中的一种配体。这种分子被称为神经细胞黏附分子（N-CAM），它参与神经发育的多个方面，包括神经丛层的形成、神经突束化以及神经-肌肉相互作用。体内实验表明，N-CAM介导的黏附对于视觉系统的有序组装至关重要。

相似文献

1
Developmental biology of a neural cell adhesion molecule.一种神经细胞黏附分子的发育生物学
Nature. 1984;310(5978):549-54. doi: 10.1038/310549a0.
2
Differential contributions of Ng-CAM and N-CAM to cell adhesion in different neural regions.Ng-CAM和N-CAM在不同神经区域对细胞黏附的不同贡献。
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Neurite outgrowth on muscle cell surfaces involves extracellular matrix receptors as well as Ca2+-dependent and -independent cell adhesion molecules.神经突在肌细胞表面的生长涉及细胞外基质受体以及钙依赖性和非钙依赖性细胞黏附分子。
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Effects of antibodies to neural cell adhesion molecule (N-CAM) on the differentiation of neuromuscular contacts between ciliary ganglion neurons and myotubes in vitro.神经细胞黏附分子（N-CAM）抗体对体外培养的睫状神经节神经元与肌管之间神经肌肉连接分化的影响。
Dev Biol. 1987 Feb;119(2):363-72. doi: 10.1016/0012-1606(87)90041-8.
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Cell adhesion molecules in neural histogenesis.神经组织发生中的细胞黏附分子
Annu Rev Physiol. 1986;48:417-30. doi: 10.1146/annurev.ph.48.030186.002221.
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Neuronal cell-cell adhesion depends on interactions of N-CAM with heparin-like molecules.
Nature. 1986;320(6061):445-7. doi: 10.1038/320445a0.
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Influences of the neural cell adhesion molecule on axon growth and guidance.
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Initial appearance and regional distribution of the neuron-glia cell adhesion molecule in the chick embryo.鸡胚中神经胶质细胞黏附分子的初始外观及区域分布
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Topological distribution of different forms of neural cell adhesion molecule in the developing chick visual system.
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Development of mammalian nerve-muscle synapses in culture: lack of interference by antibodies to the neural cell adhesion molecule N-CAM and its L2/HNK-1 carbohydrate epitope.培养条件下哺乳动物神经肌肉突触的发育：抗神经细胞黏附分子N-CAM及其L2/HNK-1碳水化合物表位的抗体无干扰作用
Neurosci Lett. 1987 Aug 5;78(3):247-52. doi: 10.1016/0304-3940(87)90368-5.

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