Seckel B R, Chiu T H, Nyilas E, Sidman R L
Plast Reconstr Surg. 1984 Aug;74(2):173-81. doi: 10.1097/00006534-198408000-00001.
The successful regeneration of a multifascicular, complete peripheral nerve through a tubular synthetic biodegradable nerve guide across a gap of 10 mm in the rat sciatic nerve is reported. The importance of the distal nerve as a source of target-derived neuronotrophic factors necessary for the successful regeneration of the proximal regenerating nerve is emphasized. A simplified research model for further investigation into and manipulation of the biological processes of nerve regeneration is described. The potential clinical utilization of this model in the management of peripheral nerve injuries and, ultimately, central nervous system lesions is mentioned.
据报道，在大鼠坐骨神经中，通过管状合成可生物降解神经导管跨越10毫米间隙成功再生了多束完整的周围神经。强调了远端神经作为近端再生神经成功再生所需的靶源性神经营养因子来源的重要性。描述了一种用于进一步研究和操纵神经再生生物学过程的简化研究模型。提及了该模型在周围神经损伤管理以及最终在中枢神经系统损伤管理中的潜在临床应用。
