• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Wistar大鼠胫神经在有间隙和无间隙的一期神经缝合中，包裹静脉段后的再生研究。

Study of tibial nerve regeneration in Wistar rats in primary neurorrhaphy with and without gap, wrapped in vein segments.

作者信息

Bastos Dos Santos Ewerton, Fernandes Marcela, Gomes Dos Santos João Baptista, Mattioli Leite Vilnei, Valente Sandra Gomes, Faloppa Flávio

机构信息

Universidade Federal de São Paulo (UNIFESP) - São Paulo, SP, Brazil.

出版信息

Acta Ortop Bras. 2012;20(3):165-9. doi: 10.1590/S1413-78522012000300006.

DOI:10.1590/S1413-78522012000300006
PMID:24453597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3718436/
Abstract

OBJECTIVE

This study compared nerve regeneration in Wistar rats, using epineural neurorrhaphy with a gap of 1.0 mm and without a gap, both wrapped with jugular vein tubes. Motor neurons in the spinal cord between L3 and S1 were used for the count, marked by exposure of the tibial nerve to Fluoro-Gold (FG).

METHOD

The tibial nerves on both sides were cut and sutured, with a gap on one side and no gap in the other. The sutures were wrapped with a jugular vein. Four months after surgery the tibial nerves were exposed to Fluoro-Gold and the motor neuron count performed in the spinal cord.

RESULTS

The results were statistically analyzed by the paired Wilcoxon test. There was a statistical difference between the groups with and without gap in relation to the motor neuron count (p=0.013).

CONCLUSION

The epineural neurorraphy without gap wrapped with jugular vein showed better results for nerve regeneration than the same procedure with gap.

LEVEL OF EVIDENCE

Experimental Study .

摘要

目的

本研究比较了Wistar大鼠的神经再生情况，采用包裹颈静脉管的无间隙和有1.0mm间隙的神经外膜缝合术。通过将胫神经暴露于荧光金（FG）标记，对L3和S1之间脊髓中的运动神经元进行计数。

方法

双侧胫神经切断并缝合，一侧有间隙，另一侧无间隙。缝合处用颈静脉包裹。术后4个月，将胫神经暴露于荧光金，并对脊髓中的运动神经元进行计数。

结果

采用配对Wilcoxon检验对结果进行统计学分析。有间隙组和无间隙组在运动神经元计数方面存在统计学差异（p = 0.013）。

结论

包裹颈静脉的无间隙神经外膜缝合术在神经再生方面比有间隙的相同手术效果更好。

证据水平

实验研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c832/3718436/0cfd04e331b6/aob-20-165-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c832/3718436/faf9e210b551/aob-20-165-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c832/3718436/c4ed7368a658/aob-20-165-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c832/3718436/40d6ed5ba0ad/aob-20-165-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c832/3718436/8efff1af340f/aob-20-165-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c832/3718436/0cfd04e331b6/aob-20-165-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c832/3718436/faf9e210b551/aob-20-165-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c832/3718436/c4ed7368a658/aob-20-165-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c832/3718436/40d6ed5ba0ad/aob-20-165-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c832/3718436/8efff1af340f/aob-20-165-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c832/3718436/0cfd04e331b6/aob-20-165-g05.jpg

相似文献

1
Study of tibial nerve regeneration in Wistar rats in primary neurorrhaphy with and without gap, wrapped in vein segments.Wistar大鼠胫神经在有间隙和无间隙的一期神经缝合中，包裹静脉段后的再生研究。
Acta Ortop Bras. 2012;20(3):165-9. doi: 10.1590/S1413-78522012000300006.
2
The effect of autogenous vein grafts on nerve repair with size discrepancy in rats: an electrophysiological and stereological analysis.自体静脉移植对大鼠神经修复时尺寸差异的影响：电生理和体视学分析
Brain Res. 2008 Mar 10;1198:171-81. doi: 10.1016/j.brainres.2008.01.013. Epub 2008 Jan 18.
3
Morphometric and Functional Analysis of Axonal Regeneration after End-to-end and End-to-side Neurorrhaphy in Rats.大鼠端对端和端侧神经缝合术后轴突再生的形态计量学与功能分析
Plast Reconstr Surg Glob Open. 2015 Apr 7;3(3):e326. doi: 10.1097/GOX.0000000000000280. eCollection 2015 Mar.
4
Comparison of functional results of nerve graft, vein graft, and vein filled with muscle graft in end-to-side neurorrhaphy.端侧神经缝合术中神经移植、静脉移植及肌肉填充静脉移植功能结果的比较。
Microsurgery. 2003;23(1):40-8. doi: 10.1002/micr.10076.
5
[Collateral sprouting at end-to-side neurorrhaphy site demonstrated by nerve fibers micro-tease technique].[通过神经纤维微分离技术显示的端侧神经缝合部位的侧支发芽]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2005 Nov;19(11):868-70.
6
Minced nerve tissue in vein grafts used as conduits in rat tibial nerves.在大鼠胫神经中用作导管的静脉移植物中的切碎神经组织。
Ann Plast Surg. 2014 Nov;73(5):540-6. doi: 10.1097/SAP.0000000000000060.
7
Comparison of regeneration results of prefabricated nerve graft, autogenous nerve graft, and vein graft in repair of nerve defects.预制神经移植物、自体神经移植物和静脉移植物修复神经缺损的再生结果比较。
Microsurgery. 2009;29(2):138-43. doi: 10.1002/micr.20586.
8
Latero-terminal neurorrhaphy without removal of the epineural sheath. Experimental study in rats.
Rev Paul Med. 1992 Nov-Dec;110(6):267-75.
9
Sutureless approach with vein grafts and mesenchymal stem cells in primary nerve repair: Functional and immunohistological results.原发性神经修复中使用静脉移植物和间充质干细胞的无缝合方法：功能和免疫组织学结果。
Microsurgery. 2018 Oct;38(7):780-789. doi: 10.1002/micr.30315. Epub 2018 Mar 1.
10
End-to-side neurorrhaphy with removal of the epineurial sheath: an experimental study in rats.切除神经外膜鞘的端侧神经缝合术：大鼠实验研究
Plast Reconstr Surg. 1994 Dec;94(7):1038-47. doi: 10.1097/00006534-199412000-00019.

引用本文的文献

1
Peripheral nerve regeneration with conduits: use of vein tubes.使用导管进行周围神经再生：静脉管的应用。
Neural Regen Res. 2015 Apr;10(4):529-33. doi: 10.4103/1673-5374.155428.
2
Bone marrow mesenchymal stem cell and vein conduit on sciatic nerve repair in rats.骨髓间充质干细胞与静脉导管对大鼠坐骨神经损伤的修复作用
Trauma Mon. 2015 Feb;20(1):e23325. doi: 10.5812/traumamon.23325. Epub 2015 Jan 17.

本文引用的文献

1
Preferential motor reinnervation: a sequential double-labeling study.优先运动神经再支配：一项序贯双重标记研究。
Restor Neurol Neurosci. 1990 Jan 1;1(3):281-7. doi: 10.3233/RNN-1990-13416.
2
Collagencontent of rabbit sciatic nerve during Wallerian degeneration.沃勒变性过程中兔坐骨神经的胶原蛋白含量
J Neurol Neurosurg Psychiatry. 1946 Oct;9(4):113-8. doi: 10.1136/jnnp.9.4.113.
3
Effect of hormonal replacement therapy in the hippocampus of ovariectomized epileptic female rats using the pilocarpine experimental model.使用毛果芸香碱实验模型研究激素替代疗法对去卵巢癫痫雌性大鼠海马的影响。
Epilepsy Res. 2008 Nov;82(1):46-56. doi: 10.1016/j.eplepsyres.2008.07.003. Epub 2008 Aug 29.
4
Bone marrow cells are able to increase vessels number during repair of sciatic nerve lesion.在坐骨神经损伤修复过程中，骨髓细胞能够增加血管数量。
J Neurosci Methods. 2008 May 15;170(1):16-24. doi: 10.1016/j.jneumeth.2007.12.009. Epub 2007 Dec 23.
5
Peripheral and spinal motor reorganization after nerve injury and repair.神经损伤与修复后外周及脊髓运动重组
J Neurotrauma. 2004 Jan;21(1):95-108. doi: 10.1089/089771504772695986.
6
Sutures alone are sufficient to support regeneration across a gap in the continuity of the sciatic nerve in rats.
Scand J Plast Reconstr Surg Hand Surg. 2000 Mar;34(1):1-8. doi: 10.1080/02844310050160105.
7
Inside-out vs. standard vein graft to repair a sensory nerve in rats.外翻式与标准静脉移植修复大鼠感觉神经的比较
Anat Rec. 1999 Nov 1;256(3):227-32. doi: 10.1002/(SICI)1097-0185(19991101)256:3<227::AID-AR2>3.0.CO;2-J.
8
Nerve regeneration through autogenous vein grafts: an SEM evaluation.通过自体静脉移植实现神经再生：扫描电子显微镜评估
J Reconstr Microsurg. 1996 May;12(4):205-10. doi: 10.1055/s-2007-1006477.
9
Nerve coaptation studies with and without a gap in rabbits.在兔身上进行的有间隙和无间隙神经吻合研究。
J Hand Surg Am. 1996 Mar;21(2):259-65. doi: 10.1016/S0363-5023(96)80113-4.
10
Inside-out vein graft promotes improved nerve regeneration in rats.外翻静脉移植物促进大鼠神经再生改善。
Microsurgery. 1993;14(9):608-18. doi: 10.1002/micr.1920140914.