Ell P J, Langford R, Pearce P, Lui D, Elliott A T, Woolf N, Williams E S
Br Heart J. 1978 Mar;40(3):226-33. doi: 10.1136/hrt.40.3.226.
99mTc-Imidodiphosphonate (99mTc-IDP) was investigated as an agent for nuclear medicine imaging of acute myocardial infarctions. For this purpose a suitable animal model was found. After coronary artery ligation reproducible myocardial infarcts were obtained with 80% of surviving animals. Scans of the myocardial infarcts were recorded with a high resolution gamma camera and good quality images were obtained. 99mTc-IDP ratios for normal and infarcted tissue were calculated and compared with similar data available from other 99mTc-labelled phosphates. With an infarct/normal ratio of 21:1, 99mTc-IDP is so far the best radiopharmaceutical for nuclear medicine imaging of necrosed heart muscle. Images of the myocardial infarcts have been recorded as early as 6 hours after infarction.
研究了99m锝-亚氨基二膦酸盐（99mTc-IDP）作为急性心肌梗死核医学成像剂的情况。为此找到了合适的动物模型。冠状动脉结扎后，80%存活的动物获得了可重复的心肌梗死。用高分辨率γ相机记录心肌梗死的扫描图像，并获得了高质量的图像。计算了正常组织和梗死组织的99mTc-IDP比值，并与其他99mTc标记磷酸盐的类似数据进行了比较。梗死/正常比值为21:1，99mTc-IDP是迄今为止用于坏死心肌核医学成像的最佳放射性药物。心肌梗死的图像早在梗死后6小时就已记录下来。
