McAfee J G, Krauss D J, Subramanian G, Thomas F D, Roskopf M, Ritter C, Lyons B, Schoonmaker J E, Finn R D
Invest Radiol. 1983 Sep-Oct;18(5):479-84. doi: 10.1097/00004424-198309000-00014.
The 3-hour biodistribution of 99mTc complexes of five diphosphonates (HMDP, NMMDP, DMAD, DPD, and APD), imidodiphosphonate (IDP), and pyrophosphate (PYP) was compared in rats with segmental renal infarction induced by a 1-hour occlusion of a renal artery branch. 95mTc labeled MDP was a reference substance in all animals. Three agents (APD, HMDP and IDP) had a higher infarct/normal kidney concentration ratio than MDP, the latter two by virtue of a lower content in normal kidney. HMDP, DPD, and IDP had very high liver concentrations. DPD showed relatively high concentrations in soft tissues and blood. The blood and kidney levels of PYP were higher than those of MDP but the infarct/normal kidney ratios were similar. None of the agents had a higher uptake in bone than MDP: four had a significantly lower uptake. The increased concentration of 99mTc MDP in the infarcts was readily seen in camera images one day after renal artery occlusion, but not at three or seven days. Increased diphosphonate uptake was accompanied by an influx of calcium in both cortex and medulla. The accumulation of diphosphonate in areas of infarction was not modified by infusions of verapamil or Captopril.
比较了五种二膦酸盐（HMDP、NMMDP、DMAD、DPD和APD）、亚氨基二膦酸盐（IDP）和焦磷酸盐（PYP）的99mTc配合物在大鼠中的3小时生物分布情况，这些大鼠通过阻断肾动脉分支1小时诱导了节段性肾梗死。95mTc标记的MDP在所有动物中作为参考物质。三种试剂（APD、HMDP和IDP）的梗死/正常肾脏浓度比高于MDP，后两者是因为正常肾脏中的含量较低。HMDP、DPD和IDP在肝脏中的浓度非常高。DPD在软组织和血液中显示出相对较高的浓度。PYP的血液和肾脏水平高于MDP，但梗死/正常肾脏比值相似。没有一种试剂在骨骼中的摄取高于MDP：四种试剂的摄取明显较低。肾动脉闭塞一天后，在相机图像中很容易看到梗死灶中99mTc MDP浓度增加，但在三天或七天时则看不到。二膦酸盐摄取增加伴随着皮质和髓质中钙的流入。维拉帕米或卡托普利的输注并未改变梗死区域中二膦酸盐的蓄积。
