Hagberg H, Glimelius B, Gronowitz S, Killander A, Källander C, Schröder T
Scand J Haematol. 1984 Jul;33(1):59-67. doi: 10.1111/j.1600-0609.1984.tb02211.x.
The prognostic value of different pretreatment laboratory and clinical findings at diagnosis was assessed in a series of 141 patients with generalized non-Hodgkin's lymphoma. Univariate and multivariate survival analysis (Cox's regression model) was performed, using serum analysis of deoxythymidine kinase (S-TK), beta 2-microglobulin, lactic dehydrogenase, alpha 1-acid glycoprotein = orosomucoid (S-alpha 1 AGP), haptoglobin and ferritin. In addition, Hb and the erythrocyte sedimentation rate (ESR) were measured. The clinical variables were age, presence or absence of B-symptoms, histopathology ('low-grade'; 'intermediate grade' and 'high-grade' malignancy) and bone marrow involvement. Of the 8 biochemical markers, all except Hb and the ESR showed a significant relationship to survival. Among the clinical variables, this finding was made for B-symptoms and histopathology. Using a multivariate analysis on all variables, S-TK was found to be the best factor for predicting duration of survival. The only significant additional information was provided by S-alpha 1 AGP. When only the clinical variables were taken into account, it was found that histopathology added significant information to that yielded by B-symptoms in the prediction of the survival time. When the biochemical variables were added to this model, only S-TK was of significant additional prognostic value.
在141例全身性非霍奇金淋巴瘤患者中，评估了诊断时不同预处理实验室检查结果和临床发现的预后价值。采用脱氧胸苷激酶血清分析（S-TK）、β2-微球蛋白、乳酸脱氢酶、α1-酸性糖蛋白=血清类粘蛋白（S-α1AGP）、触珠蛋白和铁蛋白进行单因素和多因素生存分析（Cox回归模型）。此外，还测量了血红蛋白和红细胞沉降率（ESR）。临床变量包括年龄、是否存在B症状、组织病理学（“低级别”；“中级别”和“高级别”恶性肿瘤）以及骨髓受累情况。在8种生化标志物中，除血红蛋白和ESR外，所有标志物均与生存有显著关系。在临床变量中，B症状和组织病理学也有此发现。对所有变量进行多因素分析时，发现S-TK是预测生存时间的最佳因素。唯一有显著额外信息的是S-α1AGP。仅考虑临床变量时，发现在预测生存时间方面，组织病理学比B症状提供了更多显著信息。当将生化变量添加到该模型中时，只有S-TK具有显著的额外预后价值。
