Tanaka K, Sishido T, Morimoto M, Inoue S, Takamura Y, Masumura M
Third Department of Internal Medicine, Yokohama City University School of Medicine, Japan.
Gastroenterol Jpn. 1993 Feb;28(1):51-5. doi: 10.1007/BF02775003.
To evaluate the clinical applications of serum thymidine kinase (TK) activity, we compared the results obtained with this parameter with those of other liver function tests in 27 patients with acute viral hepatitis and 16 normal controls. In those in the acute stage, the serum TK activity increased significantly to 55.5 +/- 66.5 U/L. There was no significant correlation between serum TK activity and findings for serum albumin, bilirubin, alkaline phosphatase or r-glutamyl transpeptidase. However, it did correlate significantly well with the serum activity of aspartate aminotransferase (AST) (r = 0.621, P < 0.01), alanine aminotransferase (ALT) (r = 0.551, P < 0.01), and lactate dehydrogenase (LDH) (r = 0.620, P < 0.01). Serum TK activity reached higher than 70 U/L in 8 of 11 patients with hepatitis A; however, no patients with the other types of hepatitis reached such a high level. During the recovery stage, the serum TK activity decreased significantly to 5.9 +/- 1.7 U/L (P < 0.01), and did not correlate with AST, ALT, LDH or other conventional liver function parameters. The data suggest that an elevation of serum TK in patients with acute viral hepatitis results from hepatocellular damage. A marked elevation of serum TK activity may thus provide a marker for acute hepatitis A infection.
为评估血清胸苷激酶（TK）活性的临床应用，我们比较了27例急性病毒性肝炎患者和16例正常对照者该参数的检测结果与其他肝功能检测结果。在急性期患者中，血清TK活性显著升高至55.5±66.5 U/L。血清TK活性与血清白蛋白、胆红素、碱性磷酸酶或γ-谷氨酰转肽酶的检测结果之间无显著相关性。然而，它与天冬氨酸转氨酶（AST）（r = 0.621，P < 0.01）、丙氨酸转氨酶（ALT）（r = 0.551，P < 0.01）和乳酸脱氢酶（LDH）（r = 0.620，P < 0.01）的血清活性显著相关。11例甲型肝炎患者中有8例血清TK活性高于70 U/L；然而，其他类型肝炎患者均未达到如此高的水平。在恢复期，血清TK活性显著下降至5.9±1.7 U/L（P < 0.01），且与AST、ALT、LDH或其他传统肝功能参数无关。数据表明，急性病毒性肝炎患者血清TK升高是肝细胞损伤所致。因此，血清TK活性显著升高可能为甲型肝炎感染提供一个标志物。
