Shen M, Ge H L, He Y X, Song Q L, Zhang H Z
Sci Sin B. 1984 Apr;27(4):398-406.
Qinghaosu, isolated and purified from the Chinese herb, Artemisia annua Linn, and identified as a sesquiterpene with a peroxide bridge and lactone structure, is a highly potent and non-toxic new antimalaria drug. This paper reports the immunosuppressive action of its water soluble derivative (hemisuccinate NA, QHS). The remarkable suppression by QHS of the in vitro 3HTdR incorporation by mitogen-stimulated mouse spleen cells and human peripheral lymphocytes, as well as the spontaneous incorporation by mouse thymocytes and blood cells from some leukemia patients is presented and its characteristics are described. The in vivo effect as shown by quantitative PFC is studied and the difference between the present in vitro and in vivo effects is investigated. The possible mechanism of inhibition and discrepancy in effects are discussed.
青蒿素是从中药青蒿中分离提纯出来的，被鉴定为具有过氧桥和内酯结构的倍半萜，是一种高效无毒的新型抗疟药。本文报道了其水溶性衍生物（半琥珀酸青蒿素钠，QHS）的免疫抑制作用。文中呈现了QHS对丝裂原刺激的小鼠脾细胞和人外周淋巴细胞体外3HTdR掺入的显著抑制作用，以及对小鼠胸腺细胞和一些白血病患者血细胞自发掺入的抑制作用，并描述了其特征。研究了定量PFC所示的体内效应，并探讨了目前体外和体内效应之间的差异。还讨论了抑制作用的可能机制以及效应差异。
