Sun X Z
Dept. of Immunology, Beijing Medical University.
Zhong Xi Yi Jie He Za Zhi. 1991 Jan;11(1):37-8, 6.
In this report the researches studied the immunosuppressive effects of Qinghaosu (QHS) and its derivative (DQHS). The results indicated that after 7-day successive administration i.p of QHS and DQHS at the dosage of 25-100 mg/kg, the amounts of anti-SRBC IgM PFC and IgG PFC in the murine spleen were decreased significantly (P less than 0.01). At the dosage of 100 mg/kg the QHS and DQHS were able to inhibit the DTH induced with BSA and the proliferative responses of murine spleen cells to Con A and LPS. These results suggested the suppressive effects of QHS and DQHS on both humoral and cellular immunities of mice. Interleukin-2 (IL-2) is an important mediate in the immune response and plays a critical role in the activation and differentiation of T and B lymphocytes. The results in this report showed a significant suppression of IL-2 production of murine spleen cells after 7-day administration i. p of QHS and DQHS, which suggested that the inhibition of IL-2 production could be the important one of the mechanisms of the immunosuppressive effects of QHS and DQHS.
在本报告中，研究人员研究了青蒿素（QHS）及其衍生物（双氢青蒿素，DQHS）的免疫抑制作用。结果表明，以25 - 100mg/kg的剂量腹腔注射QHS和DQHS连续7天给药后，小鼠脾脏中抗绵羊红细胞IgM空斑形成细胞（PFC）和IgG PFC的数量显著减少（P < 0.01）。在100mg/kg的剂量下，QHS和DQHS能够抑制牛血清白蛋白（BSA）诱导的迟发型超敏反应（DTH）以及小鼠脾细胞对刀豆蛋白A（Con A）和脂多糖（LPS）的增殖反应。这些结果表明QHS和DQHS对小鼠的体液免疫和细胞免疫均有抑制作用。白细胞介素-2（IL-2）是免疫反应中的一种重要介质，在T淋巴细胞和B淋巴细胞的激活与分化中起关键作用。本报告中的结果显示，腹腔注射QHS和DQHS 7天给药后，小鼠脾细胞IL-2的产生受到显著抑制，这表明抑制IL-2的产生可能是QHS和DQHS免疫抑制作用的重要机制之一。
