Blumenfeld A M, Sieling W L, Davidson A, Isaäcson M
S Afr Med J. 1984 Aug 11;66(6):207-8.
Chloroquine-resistant Plasmodium falciparum malaria has been described in East, Central and West Africa. We report on 2 patients with probable chloroquine-resistant P. falciparum malaria in south-western Africa. Both patients had been in northern SWA/Namibia and southern Angola, but had taken prophylactic chloroquine. Despite the subsequent administration of adequate courses of chloroquine therapy, the parasitaemias failed to clear completely. Eventual clinical and laboratory-proven cure was only obtained in 1 case after combined quinine and tetracycline therapy. To our knowledge, these represent the first cases of probable chloroquine-resistant P. falciparum malaria acquired in this area.
在东非、中非和西非已出现对氯喹耐药的恶性疟原虫疟疾。我们报告了2例在非洲西南部可能感染了对氯喹耐药的恶性疟原虫疟疾的患者。这两名患者都曾前往西南非洲/纳米比亚北部和安哥拉南部，但都服用了氯喹进行预防。尽管随后进行了足够疗程的氯喹治疗，但疟原虫血症并未完全清除。仅1例患者在联合使用奎宁和四环素治疗后最终获得了临床和实验室证实的治愈。据我们所知，这些是该地区首次出现的可能感染对氯喹耐药的恶性疟原虫疟疾的病例。
