Kobayashi T K, Yamaki T, Yoshino E, Higuchi T, Kamachi M
Acta Cytol. 1984 Jul-Aug;28(4):430-4.
The case presented illustrates the application of the immunoperoxidase technique to cerebrospinal fluid (CSF) cytology. The cytologic findings in a Papanicolaou-stained slide of the CSF permitted the diagnosis of a metastatic carcinoma. Positive reactions to carcinoembryonic antigen (CEA) were demonstrated in the tumor cells in the CSF sample as well as in the paraffin-embedded section of the primary rectal cancer. Rising CEA levels were also detected in both CSF and serum. The determination of cancer-associated antigens, such as CEA in the CSF specimen, may be useful in establishing the presence of metastatic tumor in the CSF.
所呈现的病例说明了免疫过氧化物酶技术在脑脊液（CSF）细胞学中的应用。脑脊液巴氏染色涂片的细胞学检查结果确诊为转移性癌。脑脊液样本中的肿瘤细胞以及原发性直肠癌石蜡包埋切片中的肿瘤细胞均对癌胚抗原（CEA）呈阳性反应。脑脊液和血清中也检测到CEA水平升高。在脑脊液标本中测定癌相关抗原，如CEA，可能有助于确定脑脊液中转移性肿瘤的存在。
