Iwa N, Yutani C, Kobayashi T K
Department of Pathology, National Cardiovascular Center, Osaka, Japan.
Diagn Cytopathol. 1988;4(4):312-5. doi: 10.1002/dc.2840040408.
A study was undertaken to evaluate the cellular findings of gastric carcinoma in cerebrospinal fluid (CSF). Immunocytochemical localization of carcinoembryonic antigen (CEA) was performed on four cases of metastatic gastric carcinoma cells in CSF samples. A positive peroxidase-antiperoxidase (PAP) reaction was obtained in all cases, with intense staining for CEA in the CSF samples as well as in the paraffin-embedded tissue sections from the primary gastric tumors. Cellular morphology and the results of immunoperoxidase staining can be studied simultaneously. We believe that the PAP method for CEA increases diagnostic accuracy of cytology in the CSF.
开展了一项研究以评估脑脊液（CSF）中胃癌的细胞学表现。对4例脑脊液样本中的转移性胃癌细胞进行癌胚抗原（CEA）的免疫细胞化学定位。所有病例均获得阳性过氧化物酶-抗过氧化物酶（PAP）反应，脑脊液样本以及原发性胃肿瘤石蜡包埋组织切片中CEA均呈强染色。细胞形态和免疫过氧化物酶染色结果可同时进行研究。我们认为CEA的PAP方法提高了脑脊液细胞学诊断的准确性。
