氯硝西泮与不安腿综合征中的振动
Clonazepam and vibration in restless legs syndrome.
作者信息
Montagna P, Sassoli de Bianchi L, Zucconi M, Cirignotta F, Lugaresi E
出版信息
Acta Neurol Scand. 1984 Jun;69(6):428-30. doi: 10.1111/j.1600-0404.1984.tb07826.x.
There have been no controlled therapeutic trials in Restless Legs Syndrome (RLS). In 6 patients with RLS, a randomized double-blind cross-over trial vs placebo showed a significant efficacy of clonazepam in improving subjective quality of sleep and leg dysaesthesia. Vibratory stimulation of the leg showed a less pronounced and non-significant effect. Clonazepam is a safe and effective drug for treatment of RLS; however its long-term efficacy needs confirmation.
目前尚无针对不宁腿综合征（RLS）的对照治疗试验。在6例RLS患者中，与安慰剂进行的随机双盲交叉试验表明，氯硝西泮在改善主观睡眠质量和腿部感觉异常方面具有显著疗效。腿部的振动刺激效果不那么明显且无统计学意义。氯硝西泮是治疗RLS的一种安全有效的药物；然而，其长期疗效有待证实。
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