Saxton C R, Gailiunas P, Helderman J H, Farkas R A, McCoy R, Diehl J, Sagalowsky A, Murphy F K, Ross E D, Silva F R
Am J Med. 1984 Aug;77(2):333-7. doi: 10.1016/0002-9343(84)90715-0.
A progressive, deteriorating neurologic disorder developed in a 28-year-old white man 10 years after he successfully received a living related donor kidney transplant. An extensive neurologic evaluation was unrevealing, including normal results of computed tomographic scanning of the brain with and without contrast medium. Repeated computed tomographic scanning after a double dose of radiocontrast medium in conjunction with delayed imaging revealed multiple areas of abnormal enhancement. This technique helped to direct brain biopsy, which led to the early diagnosis of progressive multifocal leukoencephalopathy and the institution of specific therapy.
一名28岁白人男性在成功接受活体亲属供肾移植10年后，出现了一种进行性、逐渐恶化的神经系统疾病。广泛的神经系统评估未发现异常，包括脑部计算机断层扫描（CT）平扫及增强扫描结果均正常。双倍剂量放射性造影剂联合延迟成像后的重复CT扫描显示多个异常强化区域。该技术有助于指导脑活检，从而早期诊断进行性多灶性白质脑病并开始进行特异性治疗。
