Blackwood R A, Moret J, Mandl I, Turino G M
Am Rev Respir Dis. 1984 Aug;130(2):231-6. doi: 10.1164/arrd.1984.130.2.231.
The effect of repeated intravenous injections of Escherichia coli endotoxin on lung structure and lung parenchymal elastin proportions was studied in rats rendered deficient in alpha 1-antitrypsin by administration of galactosamine. Within 24 h after endotoxin administration, polymorphonuclear leukocyte sequestration was demonstrable by microscopy and differential cell counts of pulmonary lavage fluid. Measurement of the proportions of elastin in lung parenchyma at 24 h revealed values in the normal range; 10 wk after repeated galactosamine and endotoxin administration, there was a reduction in the proportions of lung parenchymal elastin. At 10 wk, these animals showed a significant increase in the mean linear intercept and pulmonary compliance. Animals treated with endotoxin alone developed some but not all of the changes seen in the animals deficient in alpha 1-antitrypsin.
通过给予半乳糖胺使大鼠缺乏α1-抗胰蛋白酶，研究了反复静脉注射大肠杆菌内毒素对肺结构和肺实质弹性蛋白比例的影响。在内毒素给药后24小时内，通过显微镜检查和肺灌洗液的细胞分类计数可证实多形核白细胞的滞留。在24小时测量肺实质中弹性蛋白的比例，结果显示在正常范围内；在反复给予半乳糖胺和内毒素10周后，肺实质弹性蛋白的比例降低。在10周时，这些动物的平均线性截距和肺顺应性显著增加。仅接受内毒素治疗的动物出现了一些（但不是全部）α1-抗胰蛋白酶缺乏动物所见到的变化。
