Aritomi T, Yoshida M, Toyoshima H, Takihara H, Ishibashi M, Watanabe K
Second Department of Internal Medicine, School of Medicine, Fukuoka University.
Nihon Kyobu Shikkan Gakkai Zasshi. 1994 Oct;32(10):956-62.
The effects of repeated intravenous injection of E. coli endotoxin (ETX) and intraperitoneal injection of D-galactosamine (GAL), which decreases the circulating level of alpha 1-antitrypsin, on the pathophysiology of chronic lung injury was studied in rats. Four groups were prepared as follows for 8 weeks. Group 1 (control): Intravenous injection of saline. Group 2: Intravenous injection of ETX (2 mg/kg) once a week. Group 3: Intraperitoneal injection of GAL (200 mg/kg), 2 times daily on 3 consecutive days each week. Group 4: Injection of both ETX and GAL, at the same dosages as used in groups 2 and 3. Total lung capacity and static lung compliance divided by weight were high in the ETX group and the ETX + GAL group, comparative when compared with those in the control and GAL groups, even though weight gain rates in the ETX + GAL group was less than in other groups. Mean linear intercept of rats in the ETX + GAL group was significantly greater than in other groups. These results suggest that ETX + GAL-treated rats have more emphysematous changes in pulmonary function and structure.
研究了反复静脉注射大肠杆菌内毒素（ETX）和腹腔注射D-半乳糖胺（GAL）（可降低α1-抗胰蛋白酶的循环水平）对大鼠慢性肺损伤病理生理学的影响。将四组大鼠按以下方式处理8周。第1组（对照组）：静脉注射生理盐水。第2组：每周静脉注射一次ETX（2mg/kg）。第3组：每周连续3天每天腹腔注射2次GAL（200mg/kg）。第4组：注射ETX和GAL，剂量与第2组和第3组相同。尽管ETX+GAL组的体重增加率低于其他组，但与对照组和GAL组相比，ETX组和ETX+GAL组的总肺容量和体重校正后的静态肺顺应性较高。ETX+GAL组大鼠的平均线性截距显著大于其他组。这些结果表明，经ETX+GAL处理的大鼠在肺功能和结构上有更多的肺气肿改变。
