大鼠体内叶酸分解代谢产物的鉴定。
The identification of the products of folate catabolism in the rat.
作者信息
Murphy M, Boyle P H, Weir D G, Scott J M
出版信息
Br J Haematol. 1978 Feb;38(2):211-8. doi: 10.1111/j.1365-2141.1978.tb01037.x.
Abstract
Further analysis of rat urine containing labelled catabolites derived from administered 3H- or 14C-labelled folic acid is described. The results support previously described studies, and show that folate catabolism in the rat takes place by cleavage of the C9-N10 bond, and not by excretion of inactive forms of the vitamin which still contain the intact folate skeleton.
摘要
本文描述了对含有源自给予的3H或14C标记叶酸的标记代谢物的大鼠尿液的进一步分析。结果支持先前描述的研究，并表明大鼠体内叶酸的分解代谢是通过C9-N10键的断裂进行的，而不是通过排泄仍含有完整叶酸骨架的无活性维生素形式进行的。
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