对大鼠尿液中对乙酰氨基苯甲酸盐作为叶酸降解产物的鉴定。
The identification of p-acetamidobenzoate as a folate degradation product in rat urine.
作者信息
Connor M J, Pheasant A E, Blair J A
出版信息
Biochem J. 1979 Mar 15;178(3):795-797. doi: 10.1042/bj1780795.
Abstract
Within 48 h of administration of radiolabelled 10-formylfolate, folic acid and the polyglutamate derivative 10-formylfolate tetraglutamate to the rat, fragmentation products are found in the urine. The major catabolite was identified as p-acetamidobenzoate by chromatography and reverse isotope-dilution analysis.
摘要
给大鼠注射放射性标记的10-甲酰叶酸、叶酸及多聚谷氨酸衍生物10-甲酰叶酸四谷氨酸后48小时内，在尿液中发现了裂解产物。通过色谱法和反向同位素稀释分析确定主要分解代谢产物为对乙酰氨基苯甲酸。
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